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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Anal Squamous Cell Carcinoma!

Jul 23, 2023

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Introduction

Foods for Anal Squamous Cell Carcinoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Anal Squamous Cell Carcinoma, a distinct form of anal cancer, is characterized by the malignant transformation of squamous cells in the anal canal. This condition is classified under the ICD-10 coding system, which helps in its identification and tracking in medical records. The treatment of anal squamous cell carcinoma typically involves a multidisciplinary approach, including chemotherapy, radiation therapy, and sometimes surgery, depending on the stage and extent of the disease. Understanding the nature and management of this cancer is crucial, as early detection and appropriate treatment can significantly impact patient outcomes. Awareness of the symptoms and risk factors associated with anal squamous cell carcinoma is essential for timely diagnosis and effective treatment.



For Anal Squamous Cell Carcinoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Anal Squamous Cell Carcinoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Anal Squamous Cell Carcinoma?

For example does it matter if vegetable Ivy Gourd is consumed more compared to American Pokeweed? Does it make any difference if fruit Pummelo is preferred over Java Plum? Also if similar choices are made for nuts/seeds like Black Walnut over European Chestnut and for pulses like Moth Bean over Green Bean. And if what I eat matters – then how does one identify foods which are recommended for Anal Squamous Cell Carcinoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Anal Squamous Cell Carcinoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Anal Squamous Cell Carcinoma can be characterized by a unique set of biochemical pathways - the signature pathways of Anal Squamous Cell Carcinoma. Biochemical pathways like MAPK Signaling, NFKB Signaling, PI3K-AKT-MTOR Signaling, Oncogenic Histone Methylation are part of the signature definition of Anal Squamous Cell Carcinoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Curcumin, Apigenin, Quercetin, Lupeol, Formononetin. And Java Plum contains active ingredients Curcumin, Apigenin, Ellagic Acid, Lupeol, Formononetin and possibly others.

A common mistake made when deciding and choosing foods to eat for Anal Squamous Cell Carcinoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Anal Squamous Cell Carcinoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Anal Squamous Cell Carcinoma?

Personalized nutrition for cancers like Anal Squamous Cell Carcinoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Anal Squamous Cell Carcinoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Anal Squamous Cell Carcinoma

All cancers like Anal Squamous Cell Carcinoma can be characterized by a unique set of biochemical pathways – the signature pathways of Anal Squamous Cell Carcinoma. Biochemical pathways like MAPK Signaling, NFKB Signaling, PI3K-AKT-MTOR Signaling, Oncogenic Histone Methylation are part of the signature definition of Anal Squamous Cell Carcinoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Anal Squamous Cell Carcinoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Anal Squamous Cell Carcinoma when taking cancer treatment Mitomycin, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

KMT2D, PIK3CA, EP300, FBXW7 and PTEN are the top ranked reported genes for Anal Squamous Cell Carcinoma. KMT2D is reported in 27.0 % of the representative patients across all clinical trials. And PIK3CA is reported in 23.8 %. The combined population patient data cover ages from to . 41.9 % of the patient data are identified as men. The Anal Squamous Cell Carcinoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Anal Squamous Cell Carcinoma!

Food and Supplements for Anal Squamous Cell Carcinoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable IVY GOURD or AMERICAN POKEWEED?

Vegetable Ivy Gourd contains many active ingredients or bioactives such as Beta-sitosterol, Linolenic Acid, Vitamin C, Linoleic Acid. These active ingredients manipulate various biochemical pathways like Angiogenesis, NFKB Signaling, Cell Cycle and Apoptosis and others. Ivy Gourd is recommended for Anal Squamous Cell Carcinoma when ongoing cancer treatment is Mitomycin. This is because Ivy Gourd modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Mitomycin.

Some of the active ingredients or bioactives in vegetable American Pokeweed are Curcumin, Apigenin, Quercetin, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, Stem Cell Signaling and DNA Repair and others. American Pokeweed is not recommended for Anal Squamous Cell Carcinoma when ongoing cancer treatment is Mitomycin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE IVY GOURD IS RECOMMENDED OVER AMERICAN POKEWEED FOR Anal Squamous Cell Carcinoma AND TREATMENT Mitomycin.

Choose Fruit JAVA PLUM or PUMMELO?

Fruit Java Plum contains many active ingredients or bioactives such as Curcumin, Apigenin, Ellagic Acid, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like NFKB Signaling, JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and Focal Adhesion and others. Java Plum is recommended for Anal Squamous Cell Carcinoma when ongoing cancer treatment is Mitomycin. This is because Java Plum modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Mitomycin.

Some of the active ingredients or bioactives in fruit Pummelo are Curcumin, Apigenin, Quercetin, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and DNA Repair and others. Pummelo is not recommended for Anal Squamous Cell Carcinoma when ongoing cancer treatment is Mitomycin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT JAVA PLUM IS RECOMMENDED OVER PUMMELO FOR Anal Squamous Cell Carcinoma AND TREATMENT Mitomycin.

Choose Nut BLACK WALNUT or EUROPEAN CHESTNUT?

Black Walnut contains many active ingredients or bioactives such as Curcumin, Apigenin, Quercetin, Ellagic Acid, Lupeol. These active ingredients manipulate various biochemical pathways like NFKB Signaling, Cell Cycle, TWEAK Signaling and Apoptosis and others. Black Walnut is recommended for Anal Squamous Cell Carcinoma when ongoing cancer treatment is Mitomycin. This is because Black Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Mitomycin.

Some of the active ingredients or bioactives in European Chestnut are Curcumin, Apigenin, Quercetin, Ellagic Acid, Lupeol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, Stem Cell Signaling and DNA Repair and others. European Chestnut is not recommended for Anal Squamous Cell Carcinoma when ongoing cancer treatment is Mitomycin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BLACK WALNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Anal Squamous Cell Carcinoma AND TREATMENT Mitomycin.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Anal Squamous Cell Carcinoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GREEN BELL PEPPER or BROCCOLI?

Vegetable Green Bell Pepper contains many active ingredients or bioactives such as Curcumin, Quercetin, Resveratrol, Catechol, Linalool. These active ingredients manipulate various biochemical pathways like Inositol Phosphate Signaling, Angiogenesis, Insulin Signaling and P53 Signaling and others. Green Bell Pepper is recommended for risk of Anal Squamous Cell Carcinoma when associated genetic risk is EP300. This is because Green Bell Pepper increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Broccoli are Curcumin, Quercetin, Resveratrol, Catechol, Lupeol. These active ingredients manipulate various biochemical pathways like Insulin Signaling and P53 Signaling and others. Broccoli is not recommended when risk of Anal Squamous Cell Carcinoma when associated genetic risk is EP300 because it increases the signature pathways of it.

VEGETABLE GREEN BELL PEPPER IS RECOMMENDED OVER BROCCOLI FOR EP300 GENETIC RISK OF CANCER.

Choose Fruit TAMARIND or GRAPEFRUIT?

Fruit Tamarind contains many active ingredients or bioactives such as Curcumin, Apigenin, Catechol, Linalool, Lupeol. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, Insulin Signaling and Hypoxia and others. Tamarind is recommended for risk of Anal Squamous Cell Carcinoma when associated genetic risk is EP300. This is because Tamarind increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Grapefruit are Curcumin, Catechol, Lupeol, Lycopene, Formononetin. These active ingredients manipulate various biochemical pathways like Insulin Signaling and PI3K-AKT-MTOR Signaling and others. Grapefruit is not recommended when risk of Anal Squamous Cell Carcinoma when associated genetic risk is EP300 because it increases the signature pathways of it.

FRUIT TAMARIND IS RECOMMENDED OVER GRAPEFRUIT FOR EP300 GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or HICKORY NUT?

Butternut contains many active ingredients or bioactives such as Curcumin, Apigenin, Catechol, Lupeol, Lycopene. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, Insulin Signaling and P53 Signaling and others. Butternut is recommended for risk of Anal Squamous Cell Carcinoma when associated genetic risk is EP300. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Hickory Nut are Curcumin, Apigenin, Catechol, Lupeol, Lycopene. These active ingredients manipulate various biochemical pathways like Insulin Signaling and PI3K-AKT-MTOR Signaling and others. Hickory Nut is not recommended when risk of Anal Squamous Cell Carcinoma when associated genetic risk is EP300 because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER HICKORY NUT FOR EP300 GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Anal Squamous Cell Carcinoma. Anal Squamous Cell Carcinoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Anal Squamous Cell Carcinoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Ivy Gourd contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Anal Squamous Cell Carcinoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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