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What should I Eat?

is the most common question asked by cancer patients.
Choose food and nutritional supplements which reduces adverse interactions with your cancer treatment and support them.

is the most common question asked by cancer patients. Choose food and nutritional supplements which reduces adverse interactions with your cancer treatment and support them.

Get your personalized nutrition plan for cancer at 

Get your personalized nutrition plan for cancer at

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Which 3 Foods to Avoid for Anal Squamous Cell Carcinoma?

Apr 16, 2021

Home » Blogs » Which 3 Foods to Avoid for Anal Squamous Cell Carcinoma?

Highlights

No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Anal Squamous Cell Carcinoma needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.

Foods like Cabbage and Chamomile should be eaten when undergoing Mitomycin treatment for Anal Squamous Cell Carcinoma. On the same lines, foods like Anise and Cherry should be avoided with treatment of Mitomycin for this Cancer. Also, Black Seed contains an active ingredient called Thymol. Thymol has CYP (drug metabolizing enzyme) interactions with Mitomycin treatment and hence should be avoided. 

You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Anal Squamous Cell Carcinoma.



What is Anal Squamous Cell Carcinoma?

Anal Squamous Cell Carcinoma is a rare cancer that develops in the squamous cells which make up the lining of the anal canal and margin. The incidence rate of this cancer is only 0.8-1.3 per 1 lakh people per year. This cancer is commonly diagnosed in people who are over 35 years of age, however, it can occur in people of any age. It is more commonly found in white women and black men.

Anal Squamous Cell Carcinoma - Symptoms, Treatment, Diet, Foods

Anal Squamous Cell Carcinoma has prevalence of certain genetic changes. Some of the genes such as PIK3CA, FIP1L1, KMT2D, and HSD3B1 are known to have genetic abnormalities in this cancer resulting in a change of function. 

The genetic abnormalities found in this Anal Cancer can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment.  In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Anal Squamous Cell Carcinoma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of the Anal Cancer genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for this cancer may have to be redesigned.

Why Eating Right Matters for Anal Squamous Cell Carcinoma?

In Anal Squamous Cell Carcinoma, activation or inhibition of some of the biochemical pathways including Hematopoiesis, NFKB Signaling, Angiogenesis, DNA Repair, MAPK Signaling, MYC Signaling, Vitamin D Signaling and PI3K-AKT-MTOR Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Anal Squamous Cell Carcinoma, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.

Example Foods to “Not Eat” and Eat with Mitomycin treatment for Anal Squamous Cell Carcinoma

The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show an example of nutrition/diet for Anal Squamous Cell Carcinoma considering only one specific treatment.

Foods to Avoid

Anise : Anise contains active ingredients such as Apigenin, Eucalyptol, D-limonene and others. Apigenin interferes with the impact of Mitomycin in Anal Squamous Cell Carcinoma by activating a specific biochemical pathway called NFKB Signaling. Hence, do not eat Anise with Mitomycin treatment for this cancer. (Angélique Saint et al, Cancer Med., 2019; Wulfran Cacheux et al, Oncotarget., 2017)

Cherry : Cherry contains active ingredients such as Chrysin, Salicylic Acid, Linoleic Acid and others. Chrysin interferes with the impact of Mitomycin in Anal Squamous Cell Carcinoma by activating a specific biochemical pathway called NFKB Signaling. Hence, do not eat Cherry with Mitomycin treatment for this cancer. (Angélique Saint et al, Cancer Med., 2019; Wulfran Cacheux et al, Oncotarget., 2017)

Foods to Eat

Cabbage :  Cabbage contains active ingredients like Benzyl Isothiocyanate, Delphinidin, Isorhamnetin. Intake of Benzyl Isothiocyanate along with Mitomycin treatment for Anal Squamous Cell Carcinoma causes a decrease in a specific biochemical pathway which is called  PI3K-AKT-MTOR Signaling, and this is a very positive effect. Cabbage hence should be eaten with Mitomycin treatment for this cancer. (Srinivas Reddy Boreddy et al, Clin Cancer Res., 2011; Angélique Saint et al, Cancer Med., 2019; Shu-Yuan Cheng et al, Chem Biol Drug Des., 2018; Wulfran Cacheux et al, Oncotarget., 2017; Myeong-Kyun Shin et al, Clin Cancer Res., 2019)

Chamomile :  Chamomile contains active ingredients like Chrysoeriol, Retinol, Axillarin. Intake of Chrysoeriol along with Mitomycin treatment for Anal Squamous Cell Carcinoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Chamomile hence should be taken with Mitomycin treatment for this cancer. (Yang Yang et al, J Huazhong Univ Sci Technolog Med Sci., 2010; Angélique Saint et al, Cancer Med., 2019; Shu-Yuan Cheng et al, Chem Biol Drug Des., 2018; Wulfran Cacheux et al, Oncotarget., 2017; Myeong-Kyun Shin et al, Clin Cancer Res., 2019)

Should I take this Nutritional Supplement for Anal Squamous Cell Carcinoma?

Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP1A2 interactions with Mitomycin treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Mitomycin treatment efficacy in this Anal cancer. Hence, avoid taking Black Seed supplements with Mitomycin treatment for this Cancer. (Ahmed A Albassam et al, Saudi Pharm J., 2018; Angélique Saint et al, Cancer Med., 2019)

Science of Right Personalized Nutrition for Cancer

Top 10 Foods and Supplements to Avoid for Cancer

Go beyond same nutrition guidelines for everyone and make personalized decisions with confidence.

What are the Symptoms of this Cancer?

In the initial stages, most cancers including Anal Squamous Cell Carcinoma may not cause any signs or symptoms. However, as the disease progresses, it may start showing symptoms. 

Following are some of the signs and symptoms that may be caused by this Cancer.

  • Swollen lymph node in the anal areas
  • Bleeding from the anus or rectum
  • A mass in the anal canal
  • Abnormal discharge
  • Change in bowel habits
  • Change in the stool diameter
  • Pain in the anal area
  • Anal itching

Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Anal Squamous Cell Carcinoma.

What are the Treatment Options for this Cancer?

The treatment for Anal Squamous Cell Carcinoma may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history. The treatment options for this Cancer include:

  • Surgery
  • Radiation Therapy
  • Chemotherapy
  • Immunotherapy
  • Palliative Care

As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for this Anal Cancer.

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Anal Squamous Cell Carcinoma.

“What should I eat?” is the most frequently asked question to cancer dieticians and physicians. The right answer depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan keeps you safe from adverse nutrition interactions.

Get started NOW with answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

Top 10 Foods and Supplements to Avoid for Cancer

Go beyond same nutrition guidelines for everyone and make personalized decisions with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


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