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What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

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Which 3 Foods to Avoid for Smoldering Multiple Myeloma?

Apr 15, 2021

Estimated reading time: 8 minutes
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Highlights

No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Smoldering Multiple Myeloma (precursor to Multiple myeloma with no symptoms) needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment.

Foods like Aloe Vera and Barley should be eaten when undergoing Lenalidomide (Revlimid) treatment for Smoldering Multiple Myeloma. On the other hand, for Smoldering Multiple Myeloma, Arugula and Asparagus should be eaten with treatment of Dexamethasone. On the same lines, avoid foods like Lard and Tallow with treatment of Lenalidomide (Revlimid) for Smoldering Multiple Myeloma. If the treatment is Dexamethasone, then avoid Amaranth and Beetroot.

Also, Black Seed contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Dexamethasone treatment and hence should be avoided. However, there are no known CYP interactions between Black seed supplements and Lenalidomide (Revlimid) treatment for this disease condition.

You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers/precancerous conditions like Smoldering Multiple Myeloma.



What is Smoldering Multiple Myeloma?

Smoldering Multiple Myeloma is a plasma cell disorder which is also a precursor to a rare blood cancer called Multiple Myeloma, and the intermediate stage of Myeloma between the precancerous Monoclonal Gammopathy of undetermined significance (MGUS) and the active Myeloma. The incidence rate of this disorder is only 0.9 per 1 lakh people per year. It is commonly diagnosed in people who are between 50-70 years of age, however, it can occur in people of any age. It is more commonly diagnosed in men as compared to women. Also, it is more commonly found in African-Americans as compared to White population.

Smoldering Multiple Myeloma- Treatment, Diet, Foods to avoid, Symptoms

Smoldering Multiple Myeloma has prevalence of certain genetic changes. Some of the genes such as BRCA2, CDK8, CDX2, and CUL4A are known to have genetic abnormalities in this precancer condition resulting in a change of function. 

The genetic abnormalities found in this disorder can influence specific biochemical pathways to drive these disease cells to aggressive growth and survive the ongoing treatment.  In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Smoldering Multiple Myeloma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Smoldering Multiple Myeloma genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for this disease condition may have to be redesigned.

Why Eating Right Matters for Smoldering Multiple Myeloma?

In Smoldering Multiple Myeloma, activation or inhibition of some of the biochemical pathways including Apoptosis, Hypoxia, Cell Cycle, MAPK Signaling, Angiogenesis, MYC Signaling, NFKB Signaling, Epithelial To Mesenchymal Transition and PI3K-AKT-MTOR Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Smoldering Multiple Myeloma (such as Lenalidomide/Revlimid), one may have to avoid eating few other foods and supplements which can lead to adverse interactions with the treatment or may increase the progression to cancer.

Example Foods to “Not Eat” and Eat with Lenalidomide (Revlimid) treatment for Smoldering Multiple Myeloma

The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show changes in nutrition/diet for Smoldering Multiple Myeloma considering only the treatment changes.

Foods to Avoid

Lard : Lard contains active ingredients such as Myristic Acid, Palmitic Acid and others. Myristic Acid interferes with the impact of Lenalidomide in Smoldering Multiple Myeloma by activating a specific biological process called Angiogenesis. Hence, avoid foods like Lard with Lenalidomide (Revlimid) treatment for this condition.

Tallow : Tallow contains active ingredients such as Lauric Acid, Myristic Acid, Palmitic Acid and others. Lauric Acid interferes with the impact of Lenalidomide in Smoldering Multiple Myeloma by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, avoid foods like Tallow with Lenalidomide (Revlimid) treatment for this condition.

Foods to Eat

Aloe Vera :  Aloe Vera contains active ingredients like Lupeol, Acemannan, Chrysophanol. Intake of Lupeol along with Lenalidomide treatment for Smoldering Multiple Myeloma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Aloe Vera hence should be eaten with Lenalidomide (Revlimid) treatment for this condition.

Barley :  Barley contains active ingredients like Beta-sitosterol, Folic Acid, Oleic Acid. Intake of Beta-sitosterol along with Lenalidomide treatment for Smoldering Multiple Myeloma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Barley hence should be eaten with Lenalidomide (Revlimid) treatment for this condition.

Should I take this Nutritional Supplement for Smoldering Multiple Myeloma?

Black Seed : Black Seed has no known reported CYP (drug metabolizing enzyme) interactions with Lenalidomide (Revlimid) treatment. Black Seed supports the Lenalidomide (Revlimid) treatment for Smoldering Multiple Myeloma by decreasing the biochemical pathway/processes like Angiogenesis, Cell Survival, JAK-STAT Signaling, Cell Cycle, MYC Signaling, NFKB Signaling, PI3K-AKT-MTOR Signaling, WNT Beta-catenin Signaling, RAS-RAF Signaling.

Example Foods to “Not Eat” and Eat with Dexamethasone treatment for Smoldering Multiple Myeloma

Foods to Avoid

Amaranth : Amaranth contains active ingredients such as Beta-sitosterol, Folic Acid, Oleic Acid and others. Beta-sitosterol interferes with the impact of Dexamethasone in Smoldering Multiple Myeloma by blocking a specific biochemical pathway called NFKB Signaling. Hence, avoid foods like Amaranth with Dexamethasone treatment for Smoldering Multiple Myeloma.

Beetroot : Beetroot contains active ingredients such as Beta-sitosterol, Folic Acid, Oleic Acid and others. Beta-sitosterol interferes with the impact of Dexamethasone in Smoldering Multiple Myeloma by blocking a specific biochemical pathway called NFKB Signaling. Hence, avoid foods like Beetroot with Dexamethasone treatment for Smoldering Multiple Myeloma.

Foods to Eat

Arugula :  Arugula contains active ingredients like Esculin, Retinol, Erysolin. Intake of Esculin along with Dexamethasone treatment for Smoldering Multiple Myeloma causes an increase in a specific biochemical pathway which is called Apoptosis, and this is a very positive effect. Arugula hence should be eaten with Dexamethasone treatment for Smoldering Multiple Myeloma.

Asparagus :  Asparagus contains active ingredients like Oleic Acid, Isorhamnetin, Linolenic Acid. Intake of Oleic Acid along with Dexamethasone treatment for Smoldering Multiple Myeloma causes an increase in a specific biochemical pathway which is called Apoptosis, and this is a very positive effect. Asparagus hence should be eaten with Dexamethasone treatment for Smoldering Multiple Myeloma.

Foods to eat and avoid for Smoldering Multiple Myeloma

Should I take this Nutritional Supplement for Smoldering Multiple Myeloma?

Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP3A4 interactions with Dexamethasone treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Dexamethasone treatment efficacy in Smoldering Multiple Myeloma. Hence, avoid taking Black seed supplements with Dexamethasone treatment for this disease condition.

Which Foods To Avoid for Smoldering Multiple Myeloma?

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

What are the Symptoms of Smoldering Multiple Myeloma?

Smoldering Multiple Myeloma, is known as an asymptomatic precursor of Myeloma, as the patients with this order do not usually experience any symptoms.

It is characterized by ≥3 g/dL levels of serum Monoclonal M protein (an abnormal antibody produced by malignant plasma cells) and 10% or higher levels of plasma cells. 

Smoldering Multiple Myeloma do not show any symptoms of Multiple Myeloma like elevated calcium levels, end-organ damages like kidney failure, anemia and bone-lesions.

What are the Treatment Options for Smoldering Multiple Myeloma?

The treatment for Smoldering Multiple Myeloma may be decided based on the likelihood of progression to active Myeloma, cancer characteristics, patient’s general health and medical history. The treatment options for this disorder include:

  • Active Monitoring – those diagnosed with Smoldering Multiple Myeloma may not require immediate treatment and will be monitored for disease progression and any signs or symptoms of active Myeloma (such as high calcium levels, etc) regularly
  • Therapies may be used to control the progression of Smoldering Multiple Myeloma to active Multiple Myeloma for patients who are at high risk for Multiple Myeloma.
    • Chemotherapy
    • Immunotherapy

As part of the diet, avoid those foods and supplements that may adversely interact with the treatments like Revlimid and Dexamethasone used in Smoldering Multiple Myeloma patients.

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Smoldering Multiple Myeloma.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


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