No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Pituitary Neuroendocrine Tumors needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Apricot and Beetroot should be eaten when undergoing Fluorouracil treatment for Pituitary Neuroendocrine Tumors. On the same lines, avoid foods like Cauliflower and Green Bean with treatment of Fluorouracil for Pituitary Neuroendocrine Tumors. Also, Black Seed contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Fluorouracil treatment and hence should be avoided.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Pituitary Neuroendocrine Tumors.
What is Pituitary Neuroendocrine Tumors?
Pituitary Neuroendocrine Tumors are rare cancers that develop in the neuroendocrine cells (which act like nerve cells as well as hormone-making cells) in the pituitary gland located at the base of our brain. This cancer is commonly diagnosed in people who are about 40 to 50 years of age, however, it can occur in people of any age. It is slightly more commonly found in women as compared to men. (Peiqiong Luo et al, Front Endocrinol (Lausanne)., 2020)
Pituitary Neuroendocrine Tumors have prevalence of certain genetic changes. Some of the genes such as USP8, RIF1, PRKDC, and GNAS are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in these cancers can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Pituitary Neuroendocrine Tumors. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Pituitary Neuroendocrine Tumors genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for this cancer may have to be redesigned.
Why Eating Right Matters for Pituitary Neuroendocrine Tumors?
In Pituitary Neuroendocrine Tumors, activation or inhibition of some of the biochemical pathways including Vitamin D Signaling, NFKB Signaling, Oxidative Stress, PI3K-AKT-MTOR Signaling, Angiogenesis, DNA Repair, MYC Signaling and MAPK Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Pituitary Neuroendocrine Tumors, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Fluorouracil treatment for Pituitary Neuroendocrine Tumors
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show an example of nutrition/diet for Pituitary Neuroendocrine Tumors considering only one specific treatment.
Foods to Avoid with Fluorouracil treatment
Cauliflower : Cauliflower contains active ingredients such as Folic Acid, Vitamin C, Indole-3-carbinol and others. Folic Acid interferes with the impact of Fluorouracil in Pituitary Neuroendocrine Tumors by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, do not eat Cauliflower with Fluorouracil treatment for this cancer.
Green Bean : Green Bean contains active ingredients such as Folic Acid, Vitamin C, Ferulic Acid and others. Folic Acid interferes with the impact of Fluorouracil in Pituitary Neuroendocrine Tumors by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, do not eat Green Bean with Fluorouracil treatment for this cancer.
Foods to Eat with Fluorouracil treatment
Apricot : Apricot contains active ingredients like Salicylic Acid, Modified Citrus Pectin, Quercetin. Intake of Salicylic Acid along with Fluorouracil treatment for Pituitary Neuroendocrine Tumors causes a decrease in a specific biochemical pathway which is called DNA Repair, and this is a very positive effect. Apricot hence should be eaten with Fluorouracil treatment for this cancer.
Beetroot : Beetroot contains active ingredients like Vitamin E, Trans-trans-farnesol, Vitamin C. Intake of Vitamin E along with Fluorouracil treatment for Pituitary Neuroendocrine Tumors causes a decrease in a specific biochemical pathway which is called DNA Repair, and this is a very positive effect. Beetroot hence should be eaten with Fluorouracil treatment for this cancer.
Should I take this Nutritional Supplement with Fluorouracil treatment?
Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP1A2 interactions with Fluorouracil treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Fluorouracil treatment efficacy in Pituitary Neuroendocrine Tumors. Hence, avoid taking black seed supplements with Fluorouracil treatment in cancer.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
What are the Symptoms of this Cancer?
In the initial stages, most cancers including Pituitary Neuroendocrine Tumors may not cause any signs or symptoms. However, as the disease progresses, it may start showing symptoms.
Following are some of the signs and symptoms that may be caused by this cancer.
- Enlargement of the arms or legs
- Thickening of the skull and jaw
- Unexplained fatigue
- Vision problems
- Mood changes
- Changes in menstrual cycles in women
- Erectile dysfunction in men
- Cushing’s syndrome characterized by weight gain, high blood pressure, diabetes, and easy bruising
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Pituitary Neuroendocrine Tumors.
What are the Treatment Options for this Cancer?
The treatment for Pituitary Neuroendocrine Tumors may be decided based on different factors including type of the tumor, extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for Pituitary Neuroendocrine Tumors are usually to control the symptoms of the disease rather than to cure it (as it is often diagnosed after it has spread to a different location) and may include:
- Radiation therapy
- Medications like Somatostatin analogues
As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Pituitary Neuroendocrine Tumors.
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Pituitary Neuroendocrine Tumors.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.