No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Diffuse Midline Glioma needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Beetroot and Bell Pepper should be eaten when undergoing Temozolomide treatment for Diffuse Midline Glioma. On the same lines, avoid foods like Buttermilk and Japanese Pumpkin with treatment of Temozolomide for Diffuse Midline Glioma.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Diffuse Midline Glioma.
What is Diffuse Midline Glioma?
Diffuse Midline Glioma is a rare type of astrocytoma that develops in the midline structures and the brain stem. The incidence rate of this cancer is only 1 to 2 per 1 lakh people per year. This cancer is commonly diagnosed in children who are aged between 3-10 years, however, it occurs in adults as well. It is more commonly found in males as compared to females.
The H3K27M-mutant diffuse midline gliomas are usually incurable and classified as WHO grade IV tumors. Diffuse Midline Glioma patients positive for the H3K27M mutation are more susceptible to succumbing to the disease. (Victor M Lu et al, J Neurosurg Pediatr., 2018) A study published in the Journal of Clinical Oncology reported that the median overall survival in Diffuse Midline Glioma H3K27M mutant patients was 47.8 months. The study also highlighted that the median progression free survival was 21 months in the H3K27M mutant patients with Diffuse Midline Glioma.
Diffuse Midline Glioma has prevalence of certain genetic changes. Some of the genes such as IDH1, TP53, H3F3B, and TERT are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found inthis cancer can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Diffuse Midline Glioma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Diffuse Midline Glioma genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for this cancer may have to be redesigned.
Why Eating Right Matters for Diffuse Midline Glioma?
In Diffuse Midline Glioma, activation or inhibition of some of the biochemical pathways including NFKB Signaling, PI3K-AKT-MTOR Signaling, Cell Cycle, Cancer Epigenetics, DNA Repair, P53 Signaling, MAPK Signaling, RAS-RAF Signaling, JAK-STAT Signaling, TGFB Signaling, C-type Lectin Receptor Signaling, Notch Signaling and MYC Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Diffuse Midline Glioma, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Temozolomide treatment for Diffuse Midline Glioma
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show an example of nutrition/diet for Diffuse Midline Glioma considering only one specific treatment.
Foods to Avoid with Temozolomide treatment
Buttermilk : Buttermilk contains active ingredients such as Lauric Acid, Myristic Acid, Retinol and others. Lauric Acid interferes with the impact of Temozolomide in this disease by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, avoid foods like Buttermilk with Temozolomide treatment for Diffuse Midline Glioma.
Japanese Pumpkin : Japanese Pumpkin contains active ingredients such as Folic Acid, Myristic Acid, Retinol and others. Folic Acid interferes with the impact of Temozolomide in this cancer by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, avoid foods like Japanese Pumpkin with Temozolomide treatment for Diffuse Midline Glioma.
Foods to Eat with Temozolomide treatment
Beetroot : Beetroot contains active ingredients like Vitamin E, Folic Acid, Linoleic Acid. Intake of Vitamin E along with Temozolomide treatment for Diffuse Midline Glioma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Beetroot hence should be eaten with Temozolomide treatment for this cancer.
Bell Pepper : Bell Pepper contains active ingredients like Vitamin E, Capsaicin, Folic Acid. Intake of Vitamin E along with Temozolomide treatment for Diffuse Midline Glioma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Bell Pepper hence should be eaten with Temozolomide treatment for this cancer.
Should I take this Nutritional Supplement with Temozolomide treatment?
Black Seed : Black Seed has no known reported CYP (drug metabolizing enzyme) interactions with Temozolomide treatment. Black Seed supports the Temozolomide treatment for Diffuse Midline Glioma by decreasing the biochemical pathways/processes called Angiogenesis, MAPK Signaling, MYC Signaling, NFKB Signaling, Notch Signaling and PI3K-AKT-MTOR Signaling, and increasing pathways like RUNX Signaling. Hence, Black Seed may be taken along with Temozolomide treatment for this cancer.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
What are the Symptoms of this Cancer?
In the initial stages, most cancers including Diffuse Midline Glioma may not cause any signs or symptoms. However, as the disease progresses, it may start showing symptoms.
Following are some of the signs and symptoms that may be caused by this cancer:
- Swallowing difficulties
- Weakness or numbness of the arms/legs
- Speech problems
- Loss of balance
- Problems with eye movement
- Facial weakness
- Double vision
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Diffuse Midline Glioma.
What are the Treatment Options for this Cancer?
The treatment for Diffuse Midline Glioma may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for this cancer include:
- Radiation therapy
Surgery or surgery followed by radiation is the most common treatment regimen for Diffuse Midline Glioma. Radiotherapy helps to shrink the tumor. The primary role of chemotherapy is in the treatment of metastatic disease. As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for this cancer.
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Diffuse Midline Glioma.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.