Foods for Fibrosarcoma!

Introduction

Foods for Fibrosarcoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Fibrosarcoma is a type of cancer that originates in the fibrous tissues of the body. It can occur in various locations, including the foot, forearm, and finger. Accurate medical coding using the appropriate ICD-10 code is crucial for documentation. Pathology outlines provide valuable insights into the characteristics of fibrosarcoma cells. Radiology assists in the diagnosis and evaluation of fibrosarcoma, aiding in treatment planning. Treatment options for fibrosarcoma may include surgery, chemotherapy, or radiation therapy, depending on the location and stage of the tumor. Survival rates for fibrosarcoma can vary depending on individual factors, such as the extent of the disease and response to treatment. Early diagnosis and prompt treatment are important for improved outcomes. Recognizing the symptoms and risk factors associated with fibrosarcoma can help in early detection and intervention. Fibrosarcoma can also affect dogs, and the diagnosis and treatment process may differ. By seeking appropriate medical care and exploring available treatment options, individuals with fibrosarcoma can optimize their chances of a successful outcome.

For Fibrosarcoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Fibrosarcoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Fibrosarcoma?

For example does it matter if vegetable Cauliflower is consumed more compared to Olive? Does it make any difference if fruit Pummelo is preferred over Soursop? Also if similar choices are made for nuts/seeds like Common Walnut over European Chestnut and for pulses like Gram Bean over Lima Bean. And if what I eat matters – then how does one identify foods which are recommended for Fibrosarcoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Fibrosarcoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Apigenin, Curcumin, Lycopene, Quercetin, Phloretin. And Soursop contains active ingredients Apigenin, Curcumin, Emodin, Fisetin, Phloretin and possibly others.

A common mistake made when deciding and choosing foods to eat for Fibrosarcoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Fibrosarcoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Fibrosarcoma?

Personalized nutrition for cancers like Fibrosarcoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Fibrosarcoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Fibrosarcoma

All cancers like Fibrosarcoma can be characterized by a unique set of biochemical pathways – the signature pathways of Fibrosarcoma. Biochemical pathways like Apoptosis, Cell Cycle, MAPK Signaling, PI3K-AKT-MTOR Signaling are part of the signature definition of Fibrosarcoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Fibrosarcoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Fibrosarcoma when taking cancer treatment Eribulin, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

TP53, ATRX, PREX2, CYP17A1 and BRAF are the top ranked reported genes for Fibrosarcoma. TP53 is reported in 23.5 % of the representative patients across all clinical trials. And ATRX is reported in 23.5 %. The combined population patient data cover ages from to . 53.7 % of the patient data are identified as men. The Fibrosarcoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Fibrosarcoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable CAULIFLOWER or OLIVE?

Vegetable Cauliflower contains many active ingredients or bioactives such as Curcumin, Phloretin, Daidzein, Beta-sitosterol, Lupeol. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Cell Cycle, Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling and others. Cauliflower is recommended for Fibrosarcoma when ongoing cancer treatment is Eribulin. This is because Cauliflower modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Eribulin.

Some of the active ingredients or bioactives in vegetable Olive are Curcumin, Quercetin, Phloretin, Hydroxytyrosol, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Apoptosis and PI3K-AKT-MTOR Signaling and others. Olive is not recommended for Fibrosarcoma when ongoing cancer treatment is Eribulin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER OLIVE FOR Fibrosarcoma AND TREATMENT Eribulin.

Choose Fruit SOURSOP or PUMMELO?

Fruit Soursop contains many active ingredients or bioactives such as Apigenin, Curcumin, Emodin, Fisetin, Phloretin. These active ingredients manipulate various biochemical pathways like Apoptosis, Cell Cycle and MAPK Signaling and others. Soursop is recommended for Fibrosarcoma when ongoing cancer treatment is Eribulin. This is because Soursop modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Eribulin.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Curcumin, Lycopene, Quercetin, Phloretin. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling and others. Pummelo is not recommended for Fibrosarcoma when ongoing cancer treatment is Eribulin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT SOURSOP IS RECOMMENDED OVER PUMMELO FOR Fibrosarcoma AND TREATMENT Eribulin.

Choose Nut COMMON WALNUT or EUROPEAN CHESTNUT?

Common Walnut contains many active ingredients or bioactives such as Ellagic Acid, Curcumin, Quercetin, Phloretin, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Cell Cycle, Epithelial to Mesenchymal Transition and Apoptosis and others. Common Walnut is recommended for Fibrosarcoma when ongoing cancer treatment is Eribulin. This is because Common Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Eribulin.

Some of the active ingredients or bioactives in European Chestnut are Ellagic Acid, Apigenin, Curcumin, Quercetin, Phloretin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and others. European Chestnut is not recommended for Fibrosarcoma when ongoing cancer treatment is Eribulin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

COMMON WALNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Fibrosarcoma AND TREATMENT Eribulin.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Fibrosarcoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or MUSTARD SPINACH?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Apigenin, Curcumin, Lycopene, Myricetin, Lupeol. These active ingredients manipulate various biochemical pathways like MAPK Signaling, RAS-RAF Signaling, Reproductive Hormone Signaling and PI3K-AKT-MTOR Signaling and others. Giant Butterbur is recommended for risk of Fibrosarcoma when associated genetic risk is ATRX. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Mustard Spinach are Apigenin, Curcumin, Lycopene, Myricetin, Lupeol. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and Oncogenic Cancer Epigenetics and others. Mustard Spinach is not recommended when risk of Fibrosarcoma when associated genetic risk is ATRX because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER MUSTARD SPINACH FOR ATRX GENETIC RISK OF CANCER.

Choose Fruit RED RASPBERRY or GUAVA?

Fruit Red Raspberry contains many active ingredients or bioactives such as Ellagic Acid, Curcumin, Quercetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Cell Cycle Checkpoints, RAS-RAF Signaling and TGFB Signaling and others. Red Raspberry is recommended for risk of Fibrosarcoma when associated genetic risk is ATRX. This is because Red Raspberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Guava are Ellagic Acid, Apigenin, Curcumin, Quercetin, Linalool. These active ingredients manipulate various biochemical pathways like Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling and others. Guava is not recommended when risk of Fibrosarcoma when associated genetic risk is ATRX because it increases the signature pathways of it.

FRUIT RED RASPBERRY IS RECOMMENDED OVER GUAVA FOR ATRX GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Lycopene, Myricetin, Lupeol. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Cell Cycle Checkpoints, RAS-RAF Signaling and TGFB Signaling and others. Common Hazelnut is recommended for risk of Fibrosarcoma when associated genetic risk is ATRX. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Ellagic Acid, Apigenin, Curcumin, Lycopene, Myricetin. These active ingredients manipulate various biochemical pathways like Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling and others. Chestnut is not recommended when risk of Fibrosarcoma when associated genetic risk is ATRX because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR ATRX GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Fibrosarcoma. Fibrosarcoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Fibrosarcoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Cauliflower contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Fibrosarcoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Msk Impact 2017
• Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
• Pelargonidin induces antitumor effects in human osteosarcoma cells via autophagy induction, loss of mitochondrial membrane potential, G2/M cell cycle arrest and downregulation of PI3K/AKT signalling pathway.
• Brassinin Represses Invasive Potential of Lung Carcinoma Cells through Deactivation of PI3K/Akt/mTOR Signaling Cascade.
• Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs.
• Melatonin and vitamin D3 synergistically down-regulate Akt and MDM2 leading to TGFβ-1-dependent growth inhibition of breast cancer cells.
• https://www.ncbi.nlm.nih.gov/books/NBK560759
• https://my.clevelandclinic.org/health/diseases/22009-fibrosarcoma