No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Fibrosarcoma needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Barley and Blackberry should be eaten when undergoing Vincristine treatment for Fibrosarcoma. On the same lines, avoid foods like Buttermilk and Cherry with treatment of Vincristine for Fibrosarcoma. Also, Black Seed contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Vincristine treatment and hence should be avoided.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Fibrosarcoma.
What is Fibrosarcoma?
Fibrosarcoma is a rare cancer that develops from the uncontrolled overgrowth of cells called fibroblasts which creates fibrous tissue throughout the body. The incidence rate of this cancer is only 0.18 per 1 lakh people per year. This cancer is commonly diagnosed in people who are aged between 25–79 years, however, it can occur in people of any age. It is equally affected in both men and women .
Fibrosarcoma has prevalence of certain genetic changes. Some of the genes such as MTA1, PCLO, EGLN1, and FANCM are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in Fibrosarcoma can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Fibrosarcoma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Fibrosarcoma genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Fibrosarcoma nutrition may have to be redesigned.
Why Eating Right Matters for Fibrosarcoma?
In Fibrosarcoma, activation or inhibition of some of the biochemical pathways including PI3K-AKT-MTOR Signaling, MAPK Signaling, Oxidative Stress, P53 Signaling and Cell Cycle plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Fibrosarcoma, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Vincristine treatment for Fibrosarcoma
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show changes in nutrition/diet for Fibrosarcoma considering only the treatment changes.
Foods to Avoid with Vincristine treatment
Buttermilk : Buttermilk contains active ingredients such as Lauric Acid, Vitamin D3, Myristic Acid and others. Lauric Acid interferes with the impact of Vincristine in Fibrosarcoma by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, do not take Buttermilk with Vincristine treatment for Fibrosarcoma.
Cherry : Cherry contains active ingredients such as Chrysin, Salicylic Acid, Genistein and others. Chrysin interferes with the impact of Vincristine in Fibrosarcoma by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, avoid eating foods like Cherry with Vincristine treatment for Fibrosarcoma.
Foods to Eat with Vincristine treatment
Barley : Barley contains active ingredients like Beta-sitosterol, Oleic Acid, Folic Acid. Intake of Beta-sitosterol along with Vincristine treatment for Fibrosarcoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Barley hence should be eaten with Vincristine treatment for Fibrosarcoma.
Blackberry : Blackberry contains active ingredients like Hyperoside, Myricetin, Gallic Acid. Intake of Hyperoside along with Vincristine treatment for Fibrosarcoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Blackberry hence should be eaten with Vincristine treatment for Fibrosarcoma.
Should I take this Nutritional Supplement with Vincristine treatment?
Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP3A4 interactions with Vincristine treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Vincristine treatment efficacy in Fibrosarcoma. (Ahmed A Albassam et al, Saudi Pharm J., 2018; Pius S Fasinu et al, Front Oncol., 2019)
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
What are the Symptoms of Fibrosarcoma?
In the initial stages, most cancers including Fibrosarcoma may not cause any signs or symptoms. However, as the disease progresses, Fibrosarcoma may start showing symptoms.
Following are some of the signs and symptoms that may be caused by Fibrosarcoma.
- A lump or swelling
- Growing pain
- Numbness in areas where the tumor presses the nerves
- Unexplained bone fractures
- Difficulty in moving the limbs
- Unintentional weight loss
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Fibrosarcoma.
What are the Treatment Options for Fibrosarcoma?
The treatment for Fibrosarcoma may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for Fibrosarcoma include:
- Supportive Care
- Rehabilitation (physical and occupational therapy)
As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Fibrosarcoma.
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Fibrosarcoma.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.