No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Pleural Mesothelioma needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Black Pepper and Broccoli should be eaten when undergoing Pemetrexed treatment for Pleural Mesothelioma. On the same lines, Pleural Mesothelioma patients should avoid eating foods like Common Bean and Coriander with treatment of Pemetrexed.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Pleural Mesothelioma.
What is Pleural Mesothelioma?
Pleural Mesothelioma is a rare cancer that develops in the thin tissue lining the lungs called pleura. The incidence rate of this cancer is only 0.58 to 1.65 per 1 lakh people per year. (S Jane Henley, Int J Occup Environ Health., Jan-Mar 2013) This cancer is commonly diagnosed in people who are about 65 to 74 years of age, however, it can occur in people of any age. It is more commonly found in White population as compared to Hispanic, Black population and Asian/Pacific Islander.
Pleural Mesothelioma has prevalence of certain genetic changes. Some of the genes such as NF2, BAP1, TP53, and SETD2 are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in this cancer can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Pleural Mesothelioma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Pleural Mesothelioma genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid for patients while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for this cancer may have to be redesigned.
Why Eating Right Matters for Pleural Mesothelioma?
In Pleural Mesothelioma, activation or inhibition of some of the biochemical pathways including Oxidative Stress, MAPK Signaling, Hippo Signaling, DNA Repair, Wnt Beta-catenin Signaling, Epithelial To Mesenchymal Transition and PI3K-AKT-MTOR Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Pleural Mesothelioma, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Pemetrexed treatment for Pleural Mesothelioma
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show an example of nutrition/diet for Pleural Mesothelioma considering only one specific treatment.
Foods to Avoid with Pemetrexed treatment
Common Bean : Common Bean contains active ingredients such as Apigenin, Oleic Acid, Gamma-linolenic Acid and others. Apigenin interferes with the impact of Pemetrexed in Pleural Mesothelioma by activating a specific biological process called Epithelial to Mesenchymal Transition. Hence, do not eat Common Bean with Pemetrexed treatment for this cancer.
Coriander : Coriander contains active ingredients such as Angelicin, Oleic Acid, P-coumaric Acid and others. Angelicin interferes with the impact of Pemetrexed in Pleural Mesothelioma by activating a specific biochemical pathway called WNT Beta-catenin Signaling. Hence, Pleural Mesothelioma patients should avoid foods like Coriander with Pemetrexed treatment.
Foods to Eat with Pemetrexed treatment
Black Pepper : Black Pepper contains active ingredients like Piperine, Folic Acid, Oleic Acid. Intake of Piperine along with Pemetrexed treatment for Pleural Mesothelioma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Black Pepper hence should be eaten with Pemetrexed treatment for this cancer.
Broccoli : Broccoli contains active ingredients like Salicylic Acid, Folic Acid, Oleic Acid. Intake of Salicylic Acid along with Pemetrexed treatment for Pleural Mesothelioma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Broccoli hence should be eaten with Pemetrexed treatment for this cancer.
Should I take this Nutritional Supplement with Pemetrexed treatment?
Black Seed : Black Seed has no known reported CYP (drug metabolizing enzyme) interactions with Pemetrexed treatment. Black Seed supports the Pemetrexed treatment for Pleural Mesothelioma by decreasing the biochemical pathway/processes called Epithelial to Mesenchymal Transition, MAPK Signaling, PI3K-AKT-MTOR Signaling, DNA Repair, WNT Beta Catenin Signaling. Hence, avoid taking Black seed supplements with Pemetrexed treatment for this cancer.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
What are the Symptoms of Pleural Mesothelioma?
In the initial stages, most cancers including Pleural Mesothelioma may not cause any signs or symptoms. However, as the disease progresses, Pleural Mesothelioma may start showing symptoms.
Following are some of the signs and symptoms that may be caused by Pleural Mesothelioma.
- Breathing difficulties or Shortness of breath
- Chest pain or lower back pain
- Persistent cough
- Swallowing difficulties
- Unexplained weight loss
- High fever
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Pleural Mesothelioma.
What are the Treatment Options for Pleural Mesothelioma?
The treatment for Pleural Mesothelioma may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for Pleural Mesothelioma include:
- Radiation Therapy
- Palliative surgery to reduce pain due to pressure caused by fluid build up in chest
- Targeted Therapy
As part of the diet, Pleural Mesothelioma patients should avoid including those foods and supplements that may adversely interact with the treatments.
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Pleural Mesothelioma.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.