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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Oligoastrocytoma!

Jul 26, 2023

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Introduction

Foods for Oligoastrocytoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Oligoastrocytoma, a brain tumor that contains both astrocytic and oligodendroglial components, is classified by grades, with grade 2 being less aggressive compared to grades 3 and 4. The pathology outlines and histology of oligoastrocytoma are key in determining its grade and subsequent treatment plan. Radiological imaging plays a crucial role in the diagnosis, which is categorized under the ICD-10 coding system. The survival rate and prognosis of oligoastrocytoma vary depending on its grade; grade 3 oligoastrocytoma has a lower survival rate compared to grade 2, and the life expectancy decreases further with grade 4. Treatment typically involves a combination of surgery, radiation, and chemotherapy, tailored to the tumor’s characteristics. Oligoastrocytoma can be cancerous, with its nature ranging from benign in lower grades to malignant in higher grades. Understanding the differences between oligoastrocytoma and similar tumors like glioblastoma and oligodendroglioma is essential for accurate diagnosis and effective management.



For Oligoastrocytoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Oligoastrocytoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Oligoastrocytoma?

For example does it matter if vegetable Carrot is consumed more compared to White Cabbage? Does it make any difference if fruit Abiyuch is preferred over Blackberry? Also if similar choices are made for nuts/seeds like Butternut over European Chestnut and for pulses like Cowpea over Common Bean. And if what I eat matters – then how does one identify foods which are recommended for Oligoastrocytoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Oligoastrocytoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Oligoastrocytoma can be characterized by a unique set of biochemical pathways - the signature pathways of Oligoastrocytoma. Biochemical pathways like Hypoxia, Notch Signaling, Oncogenic Cancer Epigenetics, Energy Metabolism are part of the signature definition of Oligoastrocytoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Abiyuch contains active ingredients Catechol, Curcumin, Apigenin, Daidzein, Caffeine. And Blackberry contains active ingredients Cinnamaldehyde, Ellagic Acid, Linalool, Myricetin, Quercetin and possibly others.

A common mistake made when deciding and choosing foods to eat for Oligoastrocytoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Oligoastrocytoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Oligoastrocytoma?

Personalized nutrition for cancers like Oligoastrocytoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Oligoastrocytoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Oligoastrocytoma

All cancers like Oligoastrocytoma can be characterized by a unique set of biochemical pathways – the signature pathways of Oligoastrocytoma. Biochemical pathways like Hypoxia, Notch Signaling, Oncogenic Cancer Epigenetics, Energy Metabolism are part of the signature definition of Oligoastrocytoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Oligoastrocytoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Oligoastrocytoma when taking cancer treatment Procarbazine, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

IDH1, ATRX, ABL1, ARID2 and ASXL1 are the top ranked reported genes for Oligoastrocytoma. IDH1 is reported in 100.0 % of the representative patients across all clinical trials. And ATRX is reported in 50.0 %. The combined population patient data cover ages from to . 50.0 % of the patient data are identified as men. The Oligoastrocytoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Oligoastrocytoma!

Food and Supplements for Oligoastrocytoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable CARROT or WHITE CABBAGE?

Vegetable Carrot contains many active ingredients or bioactives such as Catechol, Curcumin, Apigenin, Isorhamnetin, Daidzein. These active ingredients manipulate various biochemical pathways like Notch Signaling, Hypoxia and PI3K-AKT-MTOR Signaling and others. Carrot is recommended for Oligoastrocytoma when ongoing cancer treatment is Procarbazine. This is because Carrot modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Procarbazine.

Some of the active ingredients or bioactives in vegetable White Cabbage are Catechol, Curcumin, Daidzein, Cinnamaldehyde, Benzyl Isothiocyanate. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and others. White Cabbage is not recommended for Oligoastrocytoma when ongoing cancer treatment is Procarbazine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE CARROT IS RECOMMENDED OVER WHITE CABBAGE FOR Oligoastrocytoma AND TREATMENT Procarbazine.

Choose Fruit BLACKBERRY or ABIYUCH?

Fruit Blackberry contains many active ingredients or bioactives such as Cinnamaldehyde, Ellagic Acid, Linalool, Myricetin, Quercetin. These active ingredients manipulate various biochemical pathways like Hypoxia and PI3K-AKT-MTOR Signaling and others. Blackberry is recommended for Oligoastrocytoma when ongoing cancer treatment is Procarbazine. This is because Blackberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Procarbazine.

Some of the active ingredients or bioactives in fruit Abiyuch are Catechol, Curcumin, Apigenin, Daidzein, Caffeine. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and others. Abiyuch is not recommended for Oligoastrocytoma when ongoing cancer treatment is Procarbazine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT BLACKBERRY IS RECOMMENDED OVER ABIYUCH FOR Oligoastrocytoma AND TREATMENT Procarbazine.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Catechol, Apigenin, Curcumin, Daidzein, Cinnamaldehyde. These active ingredients manipulate various biochemical pathways like Hypoxia and PI3K-AKT-MTOR Signaling and others. Butternut is recommended for Oligoastrocytoma when ongoing cancer treatment is Procarbazine. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Procarbazine.

Some of the active ingredients or bioactives in European Chestnut are Catechol, Curcumin, Apigenin, Daidzein, Cinnamaldehyde. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and others. European Chestnut is not recommended for Oligoastrocytoma when ongoing cancer treatment is Procarbazine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Oligoastrocytoma AND TREATMENT Procarbazine.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Oligoastrocytoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable CELERY STALKS or CHICORY?

Vegetable Celery Stalks contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like DNA Repair, Hypoxia, P53 Signaling and Glutathione Metabolism and others. Celery Stalks is recommended for risk of Oligoastrocytoma when associated genetic risk is ABL1. This is because Celery Stalks increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Chicory are Curcumin, Lupeol, Daidzein, Beta-sitosterol, Formononetin. These active ingredients manipulate various biochemical pathways like DNA Repair and Glutathione Metabolism and others. Chicory is not recommended when risk of Oligoastrocytoma when associated genetic risk is ABL1 because it increases the signature pathways of it.

VEGETABLE CELERY STALKS IS RECOMMENDED OVER CHICORY FOR ABL1 GENETIC RISK OF CANCER.

Choose Fruit BAEL or GRAPEFRUIT?

Fruit Bael contains many active ingredients or bioactives such as Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Auraptene. These active ingredients manipulate various biochemical pathways like Apoptosis, Hypoxia, P53 Signaling and MYC Signaling and others. Bael is recommended for risk of Oligoastrocytoma when associated genetic risk is ABL1. This is because Bael increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Grapefruit are Curcumin, Lupeol, Daidzein, Beta-sitosterol, Lycopene. These active ingredients manipulate various biochemical pathways like DNA Repair and Glutathione Metabolism and others. Grapefruit is not recommended when risk of Oligoastrocytoma when associated genetic risk is ABL1 because it increases the signature pathways of it.

FRUIT BAEL IS RECOMMENDED OVER GRAPEFRUIT FOR ABL1 GENETIC RISK OF CANCER.

Choose Nut COLORADO PINYON or JAPANESE CHESTNUT?

Colorado Pinyon contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like DNA Repair, Apoptosis, P53 Signaling and Cell Cycle Checkpoints and others. Colorado Pinyon is recommended for risk of Oligoastrocytoma when associated genetic risk is ABL1. This is because Colorado Pinyon increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Japanese Chestnut are Apigenin, Curcumin, Lupeol, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like DNA Repair and Glutathione Metabolism and others. Japanese Chestnut is not recommended when risk of Oligoastrocytoma when associated genetic risk is ABL1 because it increases the signature pathways of it.

COLORADO PINYON IS RECOMMENDED OVER JAPANESE CHESTNUT FOR ABL1 GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Oligoastrocytoma. Oligoastrocytoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Oligoastrocytoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Carrot contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Oligoastrocytoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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