No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Colorectal Neuroendocrine Tumor/Carcinoma needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Beetroot and Blueberry should be eaten when undergoing Everolimus treatment for Colorectal Neuroendocrine Tumor. On the same lines, foods like Anise and Cherry should be avoided with treatment of Everolimus for this cancer. Also, Black Seed contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Everolimus treatment and hence should be avoided.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Colorectal Neuroendocrine Tumor.
What is Colorectal Neuroendocrine Tumor?
Colorectal Neuroendocrine Tumor/Carcinoma is a rare cancer that develops in the neuroendocrine cells (which act like nerve cells as well as hormone-making cells) in the colon and rectum. The incidence rate of this cancer is only 0.2-0.86 per 1 lakh people per year. (Mengjie Jiang et al, Gastroenterol Res Pract., 2017) This cancer is commonly diagnosed in people who are about 52 years of age, however, it can occur in people of any age. It is more commonly found in Black and Asian people as compared to other ethnic groups .
Colorectal Neuroendocrine Tumor has prevalence of certain genetic changes. Some of the genes such as TP53, APC, KRAS, and SYNE1 are known to have genetic abnormalities in this cancer resulting in a change of function. (Luohai Chen et al, Clin Colorectal Cancer., 2020)
The genetic abnormalities found in this cancer can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Colorectal Neuroendocrine Tumor. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. (Richard Beliveau et al, Can Fam Physician., 2007) Hence, the triangulation of Colorectal Neuroendocrine Tumor genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for this cancer may have to be redesigned.
Why Eating Right Matters in this Cancer?
In Colorectal Neuroendocrine Tumor/Carcinoma, activation or inhibition of some of the biochemical pathways including PI3K-AKT-MTOR Signaling, MAPK Signaling, Cancer Epigenetics, JAK-STAT Signaling, Cell Cycle, Angiogenesis, MYC Signaling, Wnt Beta-catenin Signaling and Nutrient Sensing plays an important role in driving the disease.(Luohai Chen et al, Clin Colorectal Cancer., 2020) All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Colorectal Neuroendocrine Tumor, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Everolimus treatment for Colorectal Neuroendocrine Tumor
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show an example of nutrition/diet for Colorectal Neuroendocrine Tumor considering only one specific treatment.
Foods to Avoid with Everolimus treatment
Anise : Anise contains active ingredients such as Apigenin, Anethole, Oleic acid and others. Apigenin interferes with the impact of Everolimus in Colorectal Neuroendocrine Tumor by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, do not eat Anise with Everolimus treatment for this cancer.
Cherry : Cherry contains active ingredients such as Beta-sitosterol, Linolenic Acid, Oleic Acid and others. Beta-sitosterol interferes with the impact of Everolimus in Colorectal Neuroendocrine Tumor by activating a specific biological process called Nutrient sensing. Hence, do not eat Cherry with Everolimus treatment for this cancer.
Foods to Eat with Everolimus treatment
Beetroot : Beetroot contains active ingredients like Vitamin E, Retinol and Vitamin C. Intake of Vitamin E along with Everolimus treatment for Colorectal Neuroendocrine Tumor causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Beetroot hence should be eaten with Everolimus treatment for this cancer.
Blueberry : Blueberry contains active ingredients like Vitamin E, Cianidanol and Delphinidin. Intake of Vitamin E along with Everolimus treatment for Colorectal Neuroendocrine Tumor causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Blueberry hence should be eaten with Everolimus treatment for this cancer.
Should I take this Nutritional Supplement with Everolimus treatment?
Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP3A4 interactions with Everolimus treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Everolimus treatment efficacy in Colorectal Neuroendocrine Tumor. Hence, avoid taking Black Seed supplement with Everolimus treatment for this cancer.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
What are the Symptoms of Colorectal Neuroendocrine Tumor?
In the initial stages, most cancers including Colorectal Neuroendocrine Tumor/Carcinoma may not cause any signs or symptoms. However, as the disease progresses, it may start showing symptoms.
Following are some of the signs and symptoms that may be caused by Colorectal Neuroendocrine Tumor:
- Stomach pain
- Rectal pain
- Rectal bleeding
- Weight loss
- Change in bowel habit
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Colorectal Neuroendocrine Tumor.
What are the Treatment Options for Colorectal Neuroendocrine Tumor?
The treatment for Colorectal Neuroendocrine Tumor/Carcinoma may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for this cancer include:
- Targeted Therapy
- Somatostatin analogues
As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Colorectal Neuroendocrine Tumor.
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Colorectal Neuroendocrine Tumor.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.