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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Gliosarcoma!

Aug 4, 2023

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Introduction

Foods for Gliosarcoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Gliosarcoma, a rare and aggressive brain tumor often considered a variant of glioblastoma, has distinct pathological and clinical features. Pathology outlines of gliosarcoma reveal a combination of glial and sarcomatous elements, differentiating it from glioblastoma. Radiology, particularly MRI, plays a crucial role in the diagnosis, showing unique imaging characteristics. Symptoms of gliosarcoma are similar to other brain tumors, including headaches, seizures, and neurological deficits. The life expectancy and prognosis for gliosarcoma patients are generally poor, with survival rates depending on various factors such as the tumor’s location and the patient’s overall health. The ICD-10 code for gliosarcoma standardizes its classification in medical records. Understanding the causes of gliosarcoma remains a subject of ongoing research. Treatment typically involves surgery, chemotherapy, and radiotherapy, but the effectiveness can vary. The experiences of gliosarcoma survivors provide valuable insights into living with this condition. Staging of gliosarcoma, crucial for treatment planning, follows the WHO 2021 guidelines, with most cases being classified as IDH-wildtype WHO grade 4, indicative of their highly aggressive nature. End-of-life care is an important consideration in advanced stages, focusing on symptom management and quality of life. The overall management of gliosarcoma requires a multidisciplinary approach, incorporating the latest research and treatment strategies to improve outcomes for those affected by this challenging brain tumor.



For Gliosarcoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Gliosarcoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Gliosarcoma?

For example does it matter if vegetable Cauliflower is consumed more compared to Welsh Onion? Does it make any difference if fruit Pummelo is preferred over Grapefruit/pummelo Hybrid? Also if similar choices are made for nuts/seeds like Butternut over Pili Nut and for pulses like Adzuki Bean over Catjang Pea. And if what I eat matters – then how does one identify foods which are recommended for Gliosarcoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Gliosarcoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Gliosarcoma can be characterized by a unique set of biochemical pathways - the signature pathways of Gliosarcoma. Biochemical pathways like TWEAK Signaling, Growth Factor Signaling, PI3K-AKT-MTOR Signaling, Apoptosis are part of the signature definition of Gliosarcoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Quercetin, Curcumin, Apigenin, Caffeine, Lupeol. And Grapefruit/pummelo Hybrid contains active ingredients Curcumin, Apigenin, Caffeine, Lupeol, Lycopene and possibly others.

A common mistake made when deciding and choosing foods to eat for Gliosarcoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Gliosarcoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Gliosarcoma?

Personalized nutrition for cancers like Gliosarcoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Gliosarcoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Gliosarcoma

All cancers like Gliosarcoma can be characterized by a unique set of biochemical pathways – the signature pathways of Gliosarcoma. Biochemical pathways like TWEAK Signaling, Growth Factor Signaling, PI3K-AKT-MTOR Signaling, Apoptosis are part of the signature definition of Gliosarcoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Gliosarcoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Gliosarcoma when taking cancer treatment Temozolomide, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

TP53, TERT, BRAF, RB1 and PTEN are the top ranked reported genes for Gliosarcoma. TP53 is reported in 9.1 % of the representative patients across all clinical trials. And TERT is reported in 9.1 %. The combined population patient data cover ages from 52 to 80. 50.0 % of the patient data are identified as men. The Gliosarcoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Gliosarcoma!

Food and Supplements for Gliosarcoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable CAULIFLOWER or WELSH ONION?

Vegetable Cauliflower contains many active ingredients or bioactives such as Curcumin, Lupeol, Delphinidin, Daidzein, Brassinin. These active ingredients manipulate various biochemical pathways like Angiogenesis, P53 Signaling, NFKB Signaling and PI3K-AKT-MTOR Signaling and others. Cauliflower is recommended for Gliosarcoma when ongoing cancer treatment is Temozolomide. This is because Cauliflower modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Temozolomide.

Some of the active ingredients or bioactives in vegetable Welsh Onion are Curcumin, Caffeine, Lupeol, Lycopene, Delphinidin. These active ingredients manipulate various biochemical pathways like NFKB Signaling and others. Welsh Onion is not recommended for Gliosarcoma when ongoing cancer treatment is Temozolomide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER WELSH ONION FOR Gliosarcoma AND TREATMENT Temozolomide.

Choose Fruit GRAPEFRUIT/PUMMELO HYBRID or PUMMELO?

Fruit Grapefruit/pummelo Hybrid contains many active ingredients or bioactives such as Curcumin, Apigenin, Caffeine, Lupeol, Lycopene. These active ingredients manipulate various biochemical pathways like DNA Repair, TGFB Signaling, NFKB Signaling and PI3K-AKT-MTOR Signaling and others. Grapefruit/pummelo Hybrid is recommended for Gliosarcoma when ongoing cancer treatment is Temozolomide. This is because Grapefruit/pummelo Hybrid modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Temozolomide.

Some of the active ingredients or bioactives in fruit Pummelo are Quercetin, Curcumin, Apigenin, Caffeine, Lupeol. These active ingredients manipulate various biochemical pathways like DNA Repair and TGFB Signaling and others. Pummelo is not recommended for Gliosarcoma when ongoing cancer treatment is Temozolomide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT GRAPEFRUIT/PUMMELO HYBRID IS RECOMMENDED OVER PUMMELO FOR Gliosarcoma AND TREATMENT Temozolomide.

Choose Nut BUTTERNUT or PILI NUT?

Butternut contains many active ingredients or bioactives such as Curcumin, Apigenin, Caffeine, Lupeol, Lycopene. These active ingredients manipulate various biochemical pathways like DNA Repair, MYC Signaling, NFKB Signaling and PI3K-AKT-MTOR Signaling and others. Butternut is recommended for Gliosarcoma when ongoing cancer treatment is Temozolomide. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Temozolomide.

Some of the active ingredients or bioactives in Pili Nut are Curcumin, Apigenin, Caffeine, Lupeol, Lycopene. These active ingredients manipulate various biochemical pathways like DNA Repair and TGFB Signaling and others. Pili Nut is not recommended for Gliosarcoma when ongoing cancer treatment is Temozolomide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER PILI NUT FOR Gliosarcoma AND TREATMENT Temozolomide.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Gliosarcoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or BLACK CABBAGE?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, DNA Repair, Stem Cell Signaling and PI3K-AKT-MTOR Signaling and others. Giant Butterbur is recommended for risk of Gliosarcoma when associated genetic risk is BRAF. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Black Cabbage are Apigenin, Curcumin, Lupeol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like Oncogenic Cancer Epigenetics and Stem Cell Signaling and others. Black Cabbage is not recommended when risk of Gliosarcoma when associated genetic risk is BRAF because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER BLACK CABBAGE FOR BRAF GENETIC RISK OF CANCER.

Choose Fruit NANCE or ACEROLA?

Fruit Nance contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, DNA Repair, Stem Cell Signaling and PI3K-AKT-MTOR Signaling and others. Nance is recommended for risk of Gliosarcoma when associated genetic risk is BRAF. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Acerola are Apigenin, Curcumin, Quercetin, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like Oncogenic Cancer Epigenetics and Stem Cell Signaling and others. Acerola is not recommended when risk of Gliosarcoma when associated genetic risk is BRAF because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER ACEROLA FOR BRAF GENETIC RISK OF CANCER.

Choose Nut COMMON WALNUT or EUROPEAN CHESTNUT?

Common Walnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Ellagic Acid, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, DNA Repair, Cell Cycle Checkpoints and MYC Signaling and others. Common Walnut is recommended for risk of Gliosarcoma when associated genetic risk is BRAF. This is because Common Walnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in European Chestnut are Apigenin, Curcumin, Quercetin, Ellagic Acid, Lupeol. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling and others. European Chestnut is not recommended when risk of Gliosarcoma when associated genetic risk is BRAF because it increases the signature pathways of it.

COMMON WALNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR BRAF GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Gliosarcoma. Gliosarcoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Gliosarcoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Cauliflower contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Gliosarcoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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