No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Rhabdomyosarcoma needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Black Tea and Carrot should be eaten when undergoing Radiation treatment for Rhabdomyosarcoma. On the other hand, for Rhabdomyosarcoma, Evening Primrose and Mulberry should be eaten with treatment of Octreotide. On the same lines, foods like Catjang Pea should be avoided with treatment of Radiation for Rhabdomyosarcoma. If the treatment is Octreotide, then avoid Currant.
Black Seed contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Octreotide treatment and hence should be avoided. However, black seed supplements may be taken along with Radiation treatment for this cancer.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Rhabdomyosarcoma.
What is Rhabdomyosarcoma?
Rhabdomyosarcoma is a rare cancer that develops from the skeletal or voluntary muscles of the body. The incidence rate of this cancer is only 0.21 per 1 lakh people per year. This cancer is commonly diagnosed in children who are about 5 years of age, however, it can occur in people of any age. It is more commonly found in Caucasians as compared to Asians.
Rhabdomyosarcoma has prevalence of certain genetic changes. Some of the genes such as NRAS, FGFR4, KRAS, and NF1 are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in Rhabdomyosarcoma can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Rhabdomyosarcoma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Rhabdomyosarcoma genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Rhabdomyosarcoma nutrition may have to be redesigned.
Why Eating Right Matters for Rhabdomyosarcoma?
In Rhabdomyosarcoma, activation or inhibition of some of the biochemical pathways including PI3K-AKT-MTOR Signaling, MAPK Signaling, RAS-RAF Signaling, Angiogenesis, Cell Cycle and Wnt Beta-catenin Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Rhabdomyosarcoma, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Radiation treatment for Rhabdomyosarcoma
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show changes in nutrition/diet for Rhabdomyosarcoma considering only the treatment changes.
Foods to Avoid with Radiation treatment
Catjang Pea : Catjang Pea contains active ingredients such as Folic Acid, Melatonin, Palmitic Acid and others. Folic Acid interferes with the impact of Radiation in Rhabdomyosarcoma by activating a specific biochemical pathway called RAS-RAF Signaling. Hence, do not eat Catjang Pea with Radiation treatment for Rhabdomyosarcoma. (B D Cowley Jr, J Biol Chem., 1989; H A Jones et al, Semin Radiat Oncol., 2001; Angelina V. Vaseva et al, American Association for Cancer Research, September 17-20, 2019; S A Terezakis et al, Clin Oncol (R Coll Radiol)., 2013)
Foods to Eat with Radiation treatment
Black Tea : Black Tea contains active ingredients like Linalool, 3-hydroxyflavone and Isoquercitrin. Intake of Linalool along with Radiation treatment for Rhabdomyosarcoma causes a decrease in a specific biochemical pathway which is called RAS-RAF Signaling, and this is a very positive effect. Black Tea hence should be eaten with Radiation treatment for Rhabdomyosarcoma. (Boris Rodenak-Kladniew et al, Life Sci., 2018; H A Jones et al, Semin Radiat Oncol., 2001; Angelina V. Vaseva et al, American Association for Cancer Research, September 17-20, 2019; S A Terezakis et al, Clin Oncol (R Coll Radiol)., 2013)
Carrot : Carrot contains active ingredients like Linalool, Gamma-linolenic Acid and Apigenin. As mentioned above, the intake of Linalool along with Radiation treatment for Rhabdomyosarcoma causes a decrease in a specific biochemical pathway which is called RAS-RAF Signaling, and this is a very positive effect. Carrot hence should be eaten with Radiation treatment for Rhabdomyosarcoma. (Boris Rodenak-Kladniew et al, Life Sci., 2018; H A Jones et al, Semin Radiat Oncol., 2001; Angelina V. Vaseva et al, American Association for Cancer Research, September 17-20, 2019; S A Terezakis et al, Clin Oncol (R Coll Radiol)., 2013)
Should I take this Nutritional Supplement with Radiation treatment?
Black Seed : Black Seed supplements contain active ingredients like thymoquinone, carvacrol and others which have no known reported CYP (drug metabolizing enzyme) interactions with Radiation treatment. Black Seed supports the Radiation treatment for Rhabdomyosarcoma by decreasing the biochemical pathways/processes called Epithelial to Mesenchymal Transition, MAPK Signaling, MYC Signaling, PI3K-AKT-MTOR Signaling, Cell Cycle, C-type Lectin Receptor Signaling, RAS-RAF Signaling and increasing pathways like Oxidative Stress. Hence, black seed supplements may be taken along with Radiation treatment for this cancer. (Kai Fan et al, Anticancer Drugs., 2015; Yun Luo et al, Oxid Med Cell Longev., 2016; S A Terezakis et al, Clin Oncol (R Coll Radiol)., 2013)
Example Foods to “Not Eat” and Eat with Octreotide treatment for Rhabdomyosarcoma
Foods to Avoid with Octreotide treatment
Currant : Currant contains active ingredients such as Linoleic Acid, Gallic Acid, Gamma-linolenic Acid and others. Linoleic Acid interferes with the impact of Octreotide in Rhabdomyosarcoma by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, do not eat Currant with Octreotide treatment for Rhabdomyosarcoma. (Bernhard Hennig et al, J Nutr Biochem., 2006; Arman Jahangiri et al, Clin Cancer Res., 2013; Marily Theodoropoulou et al, Cancer Res., 2006)
Foods to Eat with Octreotide treatment
Evening Primrose : Evening Primrose contains active ingredients like Lupeol, Gallic Acid, Gamma-linolenic Acid. Intake of Lupeol along with Octreotide treatment for Rhabdomyosarcoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Evening Primrose hence should be eaten with Octreotide treatment for Rhabdomyosarcoma. (Lingli Zhang et al, Eur J Pharmacol., 2015; Arman Jahangiri et al, Clin Cancer Res., 2013; Marily Theodoropoulou et al, Cancer Res., 2006)
Mulberry : Mulberry contains active ingredients like Morusin, Moracin P, Resveratrol. Intake of Morusin along with Octreotide treatment for Rhabdomyosarcoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Mulberry hence should be eaten with Octreotide treatment for Rhabdomyosarcoma. (Yong Zhang et al, Curr Pharm Biotechnol., 2020; Huijie Guo et al, Mol Carcinog., 2016; Arman Jahangiri et al, Clin Cancer Res., 2013; Marily Theodoropoulou et al, Cancer Res., 2006)
Should I take this Nutritional Supplement with Octreotide treatment ?
Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP3A4 interactions with Octreotide treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Octreotide treatment efficacy in Rhabdomyosarcoma. Hence, avoid taking Black seed supplements with Octreotide treatment for Rhabdomyosarcoma. (Ahmed A Albassam et al, Saudi Pharm J., 2018; Xiaoyu Sun et al, BMC Gastroenterol., 2021)
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
What are the Symptoms of Rhabdomyosarcoma?
In the initial stages, most cancers including Rhabdomyosarcoma may not cause any signs or symptoms. However, as the disease progresses, depending on where the cancer is located, Rhabdomyosarcoma may start showing symptoms.
Following are some of the signs and symptoms that may be caused by Rhabdomyosarcoma:
- Headache, bleeding in the nose, throat or ears, bulging of the eyes and vision problems – if the cancer affects the head or neck area
- Blood in the urine or difficulty while urinating, difficulty in bowel movements, bleeding or swelling in the vagina or rectum – if the cancer affects the urinary or reproductive system
- Vomiting, stomach pain – if the cancer affects the stomach
- Swelling or lump in the affected areas such as neck, chest, back, arm, leg, or groin
- Pain in the affected area
- Redness in the affected area
- Bone pain, fatigue, persistent cough, or weight loss – in advanced cases
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Rhabdomyosarcoma.
What are the Treatment Options for Rhabdomyosarcoma?
The treatment for Rhabdomyosarcoma may be decided based on different factors including the location of the cancer, size of the tumor, stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for Rhabdomyosarcoma include:
- Radiation therapy
- Targeted therapy
As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Rhabdomyosarcoma.
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Rhabdomyosarcoma.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.