No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Myxofibrosarcoma needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Allspice and Almond should be eaten when undergoing Fluorouracil treatment for Myxofibrosarcoma. On the same lines, avoid foods like Cauliflower and Green Bean with treatment of Cisplatin for Myxofibrosarcoma. Similarly, Black Seed contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Fluorouracil treatment and hence should be avoided.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Myxofibrosarcoma.
What is Myxofibrosarcoma?
Myxofibrosarcoma is a rare soft-tissue sarcoma that develops in the extremities of elderly patients. The incidence rate of this cancer is only 0.18 per 1 lakh people per year. This cancer is commonly diagnosed in people who are about 50-70 years of age, however, it can occur in people of any age. It is more commonly found in men as compared to women.
Myxofibrosarcoma has prevalence of certain genetic changes. Some of the genes such as TP53, NCOR2, ELP2, and USP28 are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in Myxofibrosarcoma can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Myxofibrosarcoma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Myxofibrosarcoma genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Myxofibrosarcoma nutrition may have to be redesigned.
Why Eating Right Matters for Myxofibrosarcoma?
In Myxofibrosarcoma, activation or inhibition of some of the biochemical pathways including PI3K-AKT-MTOR Signaling, Vitamin D Signaling, MAPK Signaling, Oxidative Stress, DNA Repair, P53 Signaling, MYC Signaling and NFKB Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Myxofibrosarcoma, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Fluorouracil treatment for Myxofibrosarcoma
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show an example of nutrition/diet for Myxofibrosarcoma considering only one specific treatment.
Foods to Avoid with Fluorouracil treatment
Cauliflower : Cauliflower contains active ingredients such as Folic Acid, Linoleic Acid, Vitamin C and others. Folic Acid interferes with the impact of Fluorouracil in Myxofibrosarcoma by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, do not eat Cauliflower with Fluorouracil treatment for Myxofibrosarcoma. (Seong Yeon Hwang et al, Int J Mol Med., 2015, Eun-Ji Kim et al, Oncotarget., 2018; Koichi Ogura et al, Nature Communications, 2018)
Green Bean : Green Bean contains active ingredients such as Folic Acid, Astragalin, Oleic Acid and others. As mentioned before, Folic Acid interferes with the impact of Fluorouracil in Myxofibrosarcoma by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence avoid eating foods like Green Bean with Fluorouracil treatment for Myxofibrosarcoma.(Seong Yeon Hwang et al, Int J Mol Med., 2015, Eun-Ji Kim et al, Oncotarget., 2018; Koichi Ogura et al, Nature Communications, 2018)
Foods to Eat with Fluorouracil treatment
Allspice : Allspice contains active ingredients like Salicylic Acid, Methyleugenol and Gallic Acid. Intake of Salicylic Acid along with Fluorouracil treatment for Myxofibrosarcoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Allspice hence should be eaten with Fluorouracil treatment for Myxofibrosarcoma. (Seong Yeon Hwang et al, Int J Mol Med., 2015; Farhat V N Din et al, Gastroenterology., 2012; Eun-Ji Kim et al, Oncotarget., 2018; Koichi Ogura et al, Nature Communications, 2018)
Almond : Almond contains active ingredients like Salicylic Acid, Oleic Acid and Quercetin. As mentioned above, the intake of Salicylic Acid along with Fluorouracil treatment for Myxofibrosarcoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Almond hence should be eaten with Fluorouracil treatment for Myxofibrosarcoma. (Seong Yeon Hwang et al, Int J Mol Med., 2015; Farhat V N Din et al, Gastroenterology., 2012; Eun-Ji Kim et al, Oncotarget., 2018; Koichi Ogura et al, Nature Communications, 2018)
Should I take this Nutritional Supplement with Fluorouracil treatment?
Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP1A2 interactions with Fluorouracil treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Fluorouracil treatment efficacy in Myxofibrosarcoma. Hence, avoid taking black seed supplements with Fluorouracil treatment for this cancer. (Ahmed A Albassam et al, Saudi Pharm J., 2018; T Komatsu et al, Drug Metab Dispos., 2000)
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
What are the Symptoms of Myxofibrosarcoma?
In the initial stages, most cancers including Myxofibrosarcoma may not cause any signs or symptoms. However, as the disease progresses, Myxofibrosarcoma may start showing symptoms.
- The symptoms include a slow-growing, painless lump on legs or arms or trunk
- Tumors may be sited just below the skin surface or in the deep tissues
Though these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Myxofibrosarcoma.
What are the Treatment Options for Myxofibrosarcoma?
The treatment for Myxofibrosarcoma may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for Myxofibrosarcoma include:
- Radiation Therapy
- Targeted drug treatment
Surgery or surgery followed by radiation is the most common treatment regimen for Myxofibrosarcoma. Radiotherapy helps to shrink the tumor. The primary role of chemotherapy is in the treatment of metastatic disease. As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Myxofibrosarcoma.
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Myxofibrosarcoma.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.