Foods for Myxofibrosarcoma!

Introduction

Foods for Myxofibrosarcoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Myxofibrosarcoma, a type of soft tissue sarcoma often occurring in the leg, is characterized by a mix of myxoid and fibrous tissue, as detailed in pathology outlines. The diagnosis of myxofibrosarcoma, including its low-grade variant, involves radiological imaging and is classified under the ICD-10 coding system. The survival rate and prognosis of myxofibrosarcoma patients can vary, largely depending on the tumor’s grade and stage at diagnosis. Treatment typically includes surgery, with radiotherapy and chemotherapy as potential adjuvant therapies, especially in cases where there’s a high risk of recurrence or metastasis. The meaning of myxofibrosarcoma extends to its occurrence in various body parts, including rare sites like the breast. Understanding the clinical and radiological aspects of myxofibrosarcoma is crucial for effective management and improving the outcomes for individuals diagnosed with this type of cancer.

For Myxofibrosarcoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Myxofibrosarcoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Myxofibrosarcoma?

For example does it matter if vegetable Cauliflower is consumed more compared to Spinach? Does it make any difference if fruit Squashberry is preferred over Purple Mangosteen? Also if similar choices are made for nuts/seeds like Butternut over European Chestnut and for pulses like Broad Bean over Common Bean. And if what I eat matters – then how does one identify foods which are recommended for Myxofibrosarcoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Myxofibrosarcoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Squashberry contains active ingredients Apigenin, Lycopene, Isoliquiritigenin, Curcumin, Myricetin. And Purple Mangosteen contains active ingredients Apigenin, Lycopene, Isoliquiritigenin, Curcumin, Myricetin and possibly others.

A common mistake made when deciding and choosing foods to eat for Myxofibrosarcoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Myxofibrosarcoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Myxofibrosarcoma?

Personalized nutrition for cancers like Myxofibrosarcoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Myxofibrosarcoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Myxofibrosarcoma

All cancers like Myxofibrosarcoma can be characterized by a unique set of biochemical pathways – the signature pathways of Myxofibrosarcoma. Biochemical pathways like Extracellular Matrix Remodelling, Nutrient sensing, PI3K-AKT-MTOR Signaling, MAPK Signaling are part of the signature definition of Myxofibrosarcoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Myxofibrosarcoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Myxofibrosarcoma when taking cancer treatment Docetaxel, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

TP53, TERT, MUC16, RYR2 and NF1 are the top ranked reported genes for Myxofibrosarcoma. TP53 is reported in 7.6 % of the representative patients across all clinical trials. And TERT is reported in 4.8 %. The combined population patient data cover ages from 31 to 89. 50.7 % of the patient data are identified as men. The Myxofibrosarcoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Myxofibrosarcoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable CAULIFLOWER or SPINACH?

Vegetable Cauliflower contains many active ingredients or bioactives such as Isoliquiritigenin, Curcumin, Genistein, Phloretin, Lupeol. These active ingredients manipulate various biochemical pathways like Cell Cycle, Adherens junction, Nutrient sensing and Epithelial to Mesenchymal Transition and others. Cauliflower is recommended for Myxofibrosarcoma when ongoing cancer treatment is Docetaxel. This is because Cauliflower modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Docetaxel.

Some of the active ingredients or bioactives in vegetable Spinach are Quercetin, Apigenin, Isoliquiritigenin, Curcumin, Myricetin. These active ingredients manipulate various biochemical pathways like TGFB Signaling, Epithelial to Mesenchymal Transition, Focal Adhesion and NFKB Signaling and others. Spinach is not recommended for Myxofibrosarcoma when ongoing cancer treatment is Docetaxel because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER SPINACH FOR Myxofibrosarcoma AND TREATMENT Docetaxel.

Choose Fruit PURPLE MANGOSTEEN or SQUASHBERRY?

Fruit Purple Mangosteen contains many active ingredients or bioactives such as Apigenin, Lycopene, Isoliquiritigenin, Curcumin, Myricetin. These active ingredients manipulate various biochemical pathways like Cell Cycle, TGFB Signaling and Chemokine Signaling and others. Purple Mangosteen is recommended for Myxofibrosarcoma when ongoing cancer treatment is Docetaxel. This is because Purple Mangosteen modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Docetaxel.

Some of the active ingredients or bioactives in fruit Squashberry are Apigenin, Lycopene, Isoliquiritigenin, Curcumin, Myricetin. These active ingredients manipulate various biochemical pathways like TGFB Signaling, Epithelial to Mesenchymal Transition, Nutrient sensing and Focal Adhesion and others. Squashberry is not recommended for Myxofibrosarcoma when ongoing cancer treatment is Docetaxel because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT PURPLE MANGOSTEEN IS RECOMMENDED OVER SQUASHBERRY FOR Myxofibrosarcoma AND TREATMENT Docetaxel.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Apigenin, Lycopene, Isoliquiritigenin, Curcumin, Myricetin. These active ingredients manipulate various biochemical pathways like Cell Cycle, JAK-STAT Signaling, Heat Stress Response and NFKB Signaling and others. Butternut is recommended for Myxofibrosarcoma when ongoing cancer treatment is Docetaxel. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Docetaxel.

Some of the active ingredients or bioactives in European Chestnut are Quercetin, Apigenin, Isoliquiritigenin, Curcumin, Ellagic Acid. These active ingredients manipulate various biochemical pathways like TGFB Signaling, Epithelial to Mesenchymal Transition and Heat Stress Response and others. European Chestnut is not recommended for Myxofibrosarcoma when ongoing cancer treatment is Docetaxel because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Myxofibrosarcoma AND TREATMENT Docetaxel.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Myxofibrosarcoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or MALABAR SPINACH?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Apigenin, Lycopene, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle, P53 Signaling, MAPK Signaling and MYC Signaling and others. Giant Butterbur is recommended for risk of Myxofibrosarcoma when associated genetic risk is MUC16. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Malabar Spinach are Curcumin, Apigenin, Quercetin, Lycopene, Lupeol. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling and Oncogenic Cancer Epigenetics and others. Malabar Spinach is not recommended when risk of Myxofibrosarcoma when associated genetic risk is MUC16 because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER MALABAR SPINACH FOR MUC16 GENETIC RISK OF CANCER.

Choose Fruit NANCE or PUMMELO?

Fruit Nance contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle, Stem Cell Signaling, P53 Signaling and MAPK Signaling and others. Nance is recommended for risk of Myxofibrosarcoma when associated genetic risk is MUC16. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Curcumin, Apigenin, Quercetin, Lycopene, Lupeol. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling and Cell Cycle Checkpoints and others. Pummelo is not recommended when risk of Myxofibrosarcoma when associated genetic risk is MUC16 because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER PUMMELO FOR MUC16 GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Lycopene, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle, P53 Signaling, MAPK Signaling and MYC Signaling and others. Common Hazelnut is recommended for risk of Myxofibrosarcoma when associated genetic risk is MUC16. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Curcumin, Apigenin, Ellagic Acid, Lycopene, Lupeol. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling and others. Chestnut is not recommended when risk of Myxofibrosarcoma when associated genetic risk is MUC16 because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR MUC16 GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Myxofibrosarcoma. Myxofibrosarcoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Myxofibrosarcoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Cauliflower contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Myxofibrosarcoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

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