No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Pineoblastoma needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Allspice and Blackberry should be eaten when undergoing Vincristine treatment for Pineoblastoma. On the other hand, for Pineoblastoma, Beetroot and Bell Pepper should be eaten with treatment of Carboplatin. On the same lines, foods like Currant and Savory should be avoided with treatment of Vincristine for Pineoblastoma. If the treatment is Carboplatin, then avoid Common Bean and Japanese Pumpkin.
Black Seed contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Vincristine treatment and hence should be avoided. However, Black seed does not have any known CYP interactions with Carboplatin treatment.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Pineoblastoma.
What is Pineoblastoma?
Pineoblastoma is a rare cancer that develops in the cells of the brain’s pineal gland. The incidence rate of this cancer is only 0.1-0.3 per 1 lakh people per year. This cancer is commonly diagnosed in children and young adults aged between 20 and 40 years, however, it can occur in people of any age. It is slightly more commonly found in men as compared to women.
Pineoblastoma has prevalence of certain genetic changes. Some of the genes such as ATR, ATM, CREBBP, and DICER1 are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in Pineoblastoma can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Pineoblastoma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Pineoblastoma genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Pineoblastoma nutrition may have to be redesigned.
Why Eating Right Matters for Pineoblastoma?
In Pineoblastoma, activation or inhibition of some of the biochemical pathways including MAPK Signaling, DNA Repair, Notch Signaling, Ephrin Signaling, PI3K-AKT-MTOR Signaling and RUNX Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Pineoblastoma, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Vincristine treatment for Pineoblastoma
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show changes in nutrition/diet for Pineoblastoma considering only the treatment changes.
Foods to Avoid
Currant : Currant contains active ingredients such as Linoleic Acid, Oleic Acid, Gamma-linolenic Acid and others. Linoleic Acid interferes with the impact of Vincristine in Pineoblastoma by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, do not eat Currant with Vincristine treatment for Pineoblastoma. (Bernhard Hennig et al, J Nutr Biochem., 2006; Xia Xie et al, Oncol Rep., 2013; Amar Gajjar et al, J Clin Oncol., 2015)
Savory : Savory contains active ingredients such as Acacetin, Oleic Acid, Myrcene and others. Acacetin interferes with the impact of Vincristine in Pineoblastoma by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, do not eat Savory with Vincristine treatment for Pineoblastoma. (Huanhuan Ren et al, Recent Pat Anticancer Drug Discov., 2018; Xia Xie et al, Oncol Rep., 2013; Amar Gajjar et al, J Clin Oncol., 2015)
Foods to Eat
Allspice : Allspice contains active ingredients like Salicylic Acid, Vitamin C, Eugenol. Intake of Salicylic Acid along with Vincristine treatment for Pineoblastoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Allspice hence should be eaten with Vincristine treatment for Pineoblastoma. (Xiaoyang Dai et al, Clin Cancer Res., 2017; Xia Xie et al, Oncol Rep., 2013; Amar Gajjar et al, J Clin Oncol., 2015)
Blackberry : Blackberry contains active ingredients like Hyperoside, Quercetin, Ellagic Acid. Intake of Hyperoside along with Vincristine treatment for Pineoblastoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Blackberry hence should be eaten with Vincristine treatment for Pineoblastoma. (Ting Fu et al, Acta Pharmacol Sin., 2016; Xia Xie et al, Oncol Rep., 2013; Amar Gajjar et al, J Clin Oncol., 2015)
Should I take this Nutritional Supplement for Pineoblastoma?
Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP3A4 interactions with Vincristine treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Vincristine treatment efficacy in Pineoblastoma. Hence, avoid taking Black seed supplements with Vincristine treatment for this cancer. (Ahmed A Albassam et al, Saudi Pharm J., 2018; Marija Bosilkovska et al, Clin Ther., 2016)
Example Foods to “Not Eat” and Eat with Carboplatin treatment for Pineoblastoma
Foods to Avoid
Common Bean : Common Bean contains active ingredients such as Apigenin, Oleic Acid, Gamma-linolenic Acid and others. Apigenin interferes with the impact of Carboplatin in Pineoblastoma by activating a specific biological process called DNA Repair. Hence, do not eat Common Bean with Carboplatin treatment for Pineoblastoma. (Haripaul Sharma et al, PLoS One., 2014; Lainie P. Martin et al, Clin Cancer Res., 2008; Maryam Fouladi et al, Cancer., 2009)
Japanese Pumpkin : Japanese Pumpkin contains active ingredients such as Folic Acid, Vitamin C, Retinol and others. Folic Acid interferes with the impact of Carboplatin in Pineoblastoma by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, do not eat Japanese Pumpkin with Carboplatin treatment for Pineoblastoma. (Seong Yeon Hwang et al, Int J Mol Med., 2015; Maryam Fouladi et al, Cancer., 2009; Raktim Biswas et al, J Photochem Photobiol B., 2015)
Foods to Eat
Beetroot and Bell Pepper: Beetroot and Bell Pepper contain active ingredients like Vitamin E, Folic Acid and others. Intake of Vitamin E along with Carboplatin treatment for Pineoblastoma causes a decrease in a specific biological process which is called DNA Repair, and this is a very positive effect. Beetroot and Bell Pepper hence should be eaten with Carboplatin treatment for Pineoblastoma. (Yoshiyuki Mizushina et al, Biochem Biophys Res Commun., 2006; Lainie P Martin et al, Clin Cancer Res., 2008; Philip E. D. Chung et al, Nat Commun., 2020)
Should I take this Nutritional Supplement for Pineoblastoma?
Black Seed : Black Seed supplements contain active ingredients like thymoquinone, Carvacrol and others which have no known reported CYP (drug metabolizing enzyme) interactions with Carboplatin treatment. Black Seed supports the Carboplatin treatment for Pineoblastoma by decreasing the biochemical pathways/processes like MAPK Signaling, Notch Signaling, PI3K-AKT-MTOR Signaling, DNA Repair and increasing pathways like RUNX Signaling. (Yun Luo et al, Oxid Med Cell Longev., 2016; Sabnam Parbin et al, Mol Biosyst., 2016)
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
What are the Symptoms of Pineoblastoma?
In the initial stages, most cancers including Pineoblastoma may not cause any signs or symptoms. However, as the disease progresses, Pineoblastoma may start showing symptoms.
Following are some of the signs and symptoms that may be caused by Pineoblastoma.
- Vision problems
- Eye movement problems
- Loss of balance
- Speech difficulties
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Pineoblastoma.
What are the Treatment Options for Pineoblastoma?
The treatment for Pineoblastoma may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for Pineoblastoma include:
- Radiation Therapy
- Targeted drug therapy
As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Pineoblastoma.
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Pineoblastoma.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.