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What should I Eat?

is the most common question asked by cancer patients.
Choose food and nutritional supplements which reduces adverse interactions with your cancer treatment and support them.

is the most common question asked by cancer patients. Choose food and nutritional supplements which reduces adverse interactions with your cancer treatment and support them.

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Get your personalized nutrition plan for cancer at

Which 3 Foods to Avoid for Synovial Sarcoma?

Apr 6, 2021

Highlights

No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Synovial Sarcoma needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.

Foods like Almond and Apricot  should be eaten when undergoing Fluorouracil treatment for Synovial Sarcoma. On the same lines, foods like Anise and Cauliflower should be avoided with treatment of Fluorouracil for Synovial Sarcoma. 

Black Seed supplement contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Fluorouracil treatment and hence should be avoided.

You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Synovial Sarcoma.



What is Synovial Sarcoma?

Synovial Sarcoma is a rare soft tissue sarcoma that develops from the synovial tissues that surround joints. The incidence rate of this cancer is only 0.11 per 1 lakh people per year. This cancer is commonly diagnosed in people who are about 20-49 years of age, however, it can occur in people of any age. It is more commonly found in men as compared to women. 

Synovial Sarcoma - Symptoms, treatment, diet, foods

Synovial Sarcoma has prevalence of certain genetic changes. Some of the genes such as SYNE1, COL7A1, ABCB11, and PAXIP1 are known to have genetic abnormalities in this cancer resulting in a change of function. 

The genetic abnormalities found in Synovial Sarcoma can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment.  In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Synovial Sarcoma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Synovial Sarcoma genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for this cancer may have to be redesigned.

Why Eating Right Matters for Synovial Sarcoma?

In Synovial Sarcoma, activation or inhibition of some of the biochemical pathways including NFKB Signaling, Oxidative Stress, PI3K-AKT-MTOR Signaling, Angiogenesis, DNA Repair, MYC Signaling and MAPK Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Synovial Sarcoma, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.

Example Foods to “Not Eat” and Eat with Fluorouracil treatment for Synovial Sarcoma

The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show an example of nutrition/diet for Synovial Sarcoma considering only one specific treatment.

Foods to Avoid

Anise : Anise contains active ingredients such as Apigenin, Quercetin, Anethole and others. Apigenin interferes with the impact of Fluorouracil in Synovial Sarcoma by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, do not eat Anise with Fluorouracil treatment for Synovial Sarcoma. (Wei Yu et al, Evid Based Complement Alternat Med., 2017; Eun-Ji Kim et al, Oncotarget., 2018; Nicolaus Friedrichs et al, Int J Cancer., 2011)

Cauliflower : Cauliflower contains active ingredients such as Folic Acid, Vitamin C, Indole-3-carbinol and others. Folic Acid interferes with the impact of Fluorouracil in Synovial Sarcoma by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, do not eat Cauliflower with Fluorouracil treatment for Synovial Sarcoma. (B D Cowley J et al, J Biol Chem., 1989; Eun-Ji Kim et al, Oncotarget., 2018; Nicolaus Friedrichs et al, Int J Cancer., 2011)

Foods to Eat

Almond and Apricot :  Almond and Apricot contain active ingredients like Salicylic Acid, Quercetin and others. Intake of Salicylic Acid along with Fluorouracil treatment for Synovial Sarcoma causes a decrease  in a specific biochemical pathway which is called  DNA Repair, and this is a very positive effect.  Almond and Apricot hence should be eaten with Fluorouracil treatment for Synovial Sarcoma. (Xiaoqi Zhang et al, Int J Mol Med., 2018; Simonetta Pazzaglia et al, Cells., 2019; Rakesh Dachineni et al, Mol Cancer Res., 2016; Patrick E Gygli et al, Aging (Albany NY)., 2016; Soichiro S Ito et al, J Biol Chem., 2020)

Should I take this Nutritional Supplement for Synovial Sarcoma?

Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP1A2 interactions with Fluorouracil treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Fluorouracil treatment efficacy in Synovial Sarcoma. (Ahmed A Albassam et al, Saudi Pharm J., 2018; T Komatsu et al, Drug Metab Dispos., 2000)

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Top 10 Foods and Supplements to Avoid for Cancer

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What are the Symptoms of Synovial Sarcoma?

In the initial stages, most cancers including Synovial Sarcoma may not cause any signs or symptoms. However, as the disease progresses, it may start showing symptoms. 

Following are some of the signs and symptoms that may be caused by Synovial Sarcoma.

  • Lump or swelling in the affected area such as knee, hip and shoulder
  • Numbness or pain, if the tumor starts pressing on nearby nerves
  • Limited range of motion in an arm or leg

Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Synovial Sarcoma.

What are the Treatment Options for this Cancer?

The treatment for Synovial Sarcoma may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for this cancer include:

  • Surgery
  • Chemotherapy
  • Radiotherapy
  • Targeted Therapy

Surgery or surgery followed by radiation is the most common treatment regimen for Synovial Sarcoma. Radiotherapy helps to shrink the tumor. As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Synovial Sarcoma.

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Synovial Sarcoma.

“What should I eat?” is the most frequently asked question to cancer dieticians and physicians. The right answer depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan keeps you safe from adverse nutrition interactions.

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Top 10 Foods and Supplements to Avoid for Cancer

Go beyond same nutrition guidelines for everyone and make personalized decisions with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.