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What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

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Which 3 Foods to Avoid for Hepatoblastoma?

Mar 31, 2021

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Highlights

No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Hepatoblastoma needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.

Foods like Aloe Vera and Burdock should be eaten when undergoing Cisplatin treatment for Hepatoblastoma. On the other hand, for Hepatoblastoma, Allspice and Almond should be eaten with treatment of Fluorouracil. On the same lines, foods like Amaranth and Beetroot should be avoided with treatment of Cisplatin for Hepatoblastoma. If the treatment is Fluorouracil, then avoid Caraway and Cauliflower.

Black Seed contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Cisplatin and Fluorouracil treatments and hence should be avoided while undergoing these treatments for Hepatoblastoma.

You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Hepatoblastoma.



What is Hepatoblastoma?

Hepatoblastoma is a rare cancer that develops in the liver. The incidence rate of this cancer is only 0.19 patients per 100,000 children per year (Tie-Cheng Feng et al, Ann Transl Med., 2019) This cancer is commonly diagnosed in children under 3 years of age, however, it can occur in people of any age. It is more commonly found in children as compared to adults.

Hepatoblastoma  - Symptoms, Treatment, Diet, Foods

Hepatoblastoma has prevalence of certain genetic changes. Some of the genes such as CTNNB1, NCOA3, NFE2L2, and PTPRT are known to have genetic abnormalities in this cancer resulting in a change of function. 

The genetic abnormalities found in Hepatoblastoma can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment.  In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Hepatoblastoma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Hepatoblastoma genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Hepatoblastoma nutrition may have to be redesigned.

Why Eating Right Matters for Hepatoblastoma?

In Hepatoblastoma, activation or inhibition of some of the biochemical pathways including Oxidative Stress, DNA Repair, Adherens Junction, MYC Signaling, WNT Beta-catenin Signaling, Epithelial To Mesenchymal Transition and PI3K-AKT-MTOR Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Hepatoblastoma, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.

Example Foods to “Not Eat” and Eat with Cisplatin treatment for Hepatoblastoma

The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show changes in nutrition/diet for Hepatoblastoma considering only the treatment changes.

Foods to Avoid

Amaranth and Beetroot : Amaranth and Beetroot contain active ingredients such as Citric Acid, Folic Acid, Oleic Acid and others. Citric Acid interferes with the impact of Cisplatin in Hepatoblastoma by activating a specific biological process called Oxidative Stress. Hence, do not eat Amaranth and Beetroot with Cisplatin treatment for Hepatoblastoma. (Omar M E Abdel-Salam et al, J Med Food., 2014; Wangie Yu et al, Scientific Reports., 2018; J Pritchard et al, J Clin Oncol., 2000)

Foods to Eat

Aloe Vera :  Aloe Vera contains active ingredients like Lupeol, Acemannan, Chrysophanol. Intake of Lupeol along with Cisplatin treatment for Hepatoblastoma causes a decrease  in a specific biological process which is called Epithelial to Mesenchymal Transition, and this is a very positive effect.  Aloe Vera hence should be eaten with Cisplatin treatment for Hepatoblastoma. (Bo-Jia Liu et al, Zhongguo Zhong Yao Za Zhi., 2020; Mital Bhatt et al, Anticancer Agents Med Chem., 2021; Guodong Xu et al, BMC Pulm Med., 2014; Gianluigi Giannelli et al, J Hepatol., 2016)

Burdock :  Burdock contains active ingredients like Dehydrocostus Lactone, Oleic Acid, Linolenic Acid. Intake of Dehydrocostus Lactone along with Cisplatin treatment for Hepatoblastoma causes a decrease in a biological process which is called Epithelial to Mesenchymal Transition, and this is a very positive effect.  Burdock hence should be eaten with Cisplatin treatment for Hepatoblastoma. (Gitanjali Javir et al, J Steroid Biochem Mol Biol., 2020; Guodong Xu et al, BMC Pulm Med., 2014; Gianluigi Giannelli et al, J Hepatol., 2016)

Should I take this Nutritional Supplement for Hepatoblastoma?

Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP3A4 interactions with Cisplatin treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Cisplatin treatment efficacy in Hepatoblastoma. Hence avoid taking black seed supplements with Cisplatin treatment for Hepatoblastoma. (Ahmed A Albassam et al, Saudi Pharm J., 2018; Pius S Fasinu et al, Front Oncol., 2019)

Example Foods to “Not Eat” and Eat with Fluorouracil treatment for Hepatoblastoma

Foods to Avoid

Caraway and Cauliflower : Caraway and Cauliflower contain active ingredients such as Folic Acid, Linolenic Acid and others. Folic Acid interferes with the impact of Fluorouracil in Hepatoblastoma by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, do not eat Caraway and Cauliflower with Fluorouracil treatment for Hepatoblastoma. (Seong Yeon Hwang et al, Int J Mol Med., 2015; Wolfgang Hartmann et al, Clin Cancer Res., 2009; Eun-Ji Kim et al, Oncotarget., 2018; J A Ortega et al, J Clin Oncol., 2000)

Foods to Eat

Allspice :  Allspice contains active ingredients like Salicylic Acid, Vitamin C and Eugenol. Intake of Salicylic Acid along with Fluorouracil treatment for Hepatoblastoma causes a decrease  in a specific biochemical pathway which is called  PI3K-AKT-MTOR Signaling, and this is a very positive effect.  Allspice hence should be eaten with Fluorouracil treatment for Hepatoblastoma. (Ronglin Jiang et al, Inflammation., 2016; Eun-Ji Kim et al, Oncotarget., 2018; Jinbo Fu et al, Sci Rep., 2019; J A Ortega et al, J Clin Oncol., 2000)

Almond :  Almond contains active ingredients like Salicylic Acid, Oleic Acid and Linolenic Acid. As mentioned above, the intake of Salicylic Acid along with Fluorouracil treatment for Hepatoblastoma causes a decrease  in a specific biochemical pathway which is called  PI3K-AKT-MTOR Signaling, and this is a very positive effect. Almond hence should be eaten with Fluorouracil treatment for Hepatoblastoma. (Ronglin Jiang et al, Inflammation., 2016; Eun-Ji Kim et al, Oncotarget., 2018; Jinbo Fu et al, Sci Rep., 2019; J A Ortega et al, J Clin Oncol., 2000)

Foods to eat and avoid for Hepatoblastoma

Should I take this Nutritional Supplement for Hepatoblastoma?

Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP1A2 interactions with Fluorouracil treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Fluorouracil treatment efficacy in Hepatoblastoma. (Ahmed A Albassam et al, Saudi Pharm J., 2018; T Komatsu et al, Drug Metab Dispos., 2000)

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

What are the Symptoms of Hepatoblastoma?

In the initial stages, most cancers including Hepatoblastoma may not cause any signs or symptoms. However, as the disease progresses, Hepatoblastoma may start showing symptoms based on the size of the tumor. 

Following are some of the signs and symptoms that may be caused by Hepatoblastoma.

  • Lump in the abdomen
  • Swollen abdomen
  • Stomach pain
  • Lack of appetite
  • Fever
  • Diarrhea
  • Dark urine
  • Back pain
  • Nausea
  • Unexplained weight loss
  • Jaundice
  • Itching

Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Hepatoblastoma.

What are the Treatment Options for Hepatoblastoma?

The treatment for Hepatoblastoma may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for Hepatoblastoma include:

  • Surgery
  • Radiation therapy
  • Chemotherapy
  • Targeted drug therapy
  • Liver Transplantation
  • Palliative Care

Surgery or surgery followed by radiation is the most common treatment regimen for Hepatoblastoma. Radiotherapy helps to shrink the tumor. The primary role of chemotherapy is to kill rapidly growing cells, including cancer cells. As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Hepatoblastoma.

Which 3 Foods to Avoid for Hepatoblastoma?

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Hepatoblastoma.

“What should I eat?” is the most frequently asked question to cancer dieticians and physicians. The right answer depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan keeps you safe from adverse nutrition interactions.

Get started NOW with answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


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