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What should I Eat?

is the most common question asked by cancer patients.
Choose food and nutritional supplements which reduces adverse interactions with your cancer treatment and support them.

is the most common question asked by cancer patients. Choose food and nutritional supplements which reduces adverse interactions with your cancer treatment and support them.

Get your personalized nutrition plan for cancer at 

Get your personalized nutrition plan for cancer at

Which 3 Foods to Avoid for Erdheim Chester Disease?

Mar 30, 2021

Highlights

No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Erdheim Chester Disease needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.

Foods like Beetroot and Cardamom should be eaten when undergoing Vemurafenib treatment for Erdheim Chester Disease. On the same lines, foods like Buttermilk and Common Bean should be avoided with treatment of Vemurafenib for this cancer.

Black Seed contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Vemurafenib treatment and hence should be avoided.

You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Erdheim Chester Disease.



What is Erdheim Chester Disease?

Erdheim Chester Disease is a rare type of slow-growing blood cancer characterized by an abnormally high number of white blood cells called histiocytes or tissue macrophages. It is also known as a non-Langerhans-cell histiocytosis. This cancer is commonly diagnosed in people who are about 40-60 years of age, however, it can occur in people of any age. It is more commonly found in men as compared to women. (Sultan Alotaibi et al, Case Rep Oncol., 2017)

Erdheim Chester Disease - Symptoms, Treatment, diet, foods

Erdheim Chester Disease has prevalence of certain genetic changes. Some of the genes such as BRAF, MAP2K1, DNMT3A, and ARAF are known to have genetic abnormalities in this cancer resulting in a change of function. 

The genetic abnormalities found in Erdheim Chester Disease can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment.  In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Erdheim Chester Disease. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Erdheim Chester Disease genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Erdheim Chester Disease nutrition may have to be redesigned. 

Why Eating Right Matters for Erdheim Chester Disease?

In Erdheim Chester Disease, activation or inhibition of some of the biochemical pathways including Ras-raf Signaling, Notch Signaling, Pi3k-akt-mtor Signaling, Mapk Signaling, Epithelial To Mesenchymal Transition, Dna Repair, Growth Factor Signaling and Myc Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Erdheim Chester Disease, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.

Example Foods to “Not Eat” and Eat with Vemurafenib treatment for Erdheim Chester Disease

The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show changes in nutrition/diet for Erdheim Chester Disease considering only the treatment changes.

Foods to Avoid

Buttermilk : Buttermilk contains active ingredients such as Lauric Acid, Myristic Acid, Vitamin D3 and others. Lauric Acid interferes with the impact of Vemurafenib in Erdheim Chester Disease by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, do not eat Buttermilk with Vemurafenib treatment for this cancer. (Ronald P Mensink et al, m J Clin Nutr., 2003; D M Rocha et al, Atherosclerosis., 2016; Yingying Meng et al, J Agric Food Chem., 2017; Daniele Perna et al, Proc Natl Acad Sci U S A., 2015; Eli L Diamond et al, JAMA Oncol., 2018)

Common Bean : Common Bean contains active ingredients such as Apigenin, Linolenic Acid, P-coumaric Acid and others. Apigenin interferes with the impact of Vemurafenib in Erdheim Chester Disease by activating a specific biological process called DNA Repair. Apigenin also has known CYP3A4 interactions with Vemurafenib treatment. Hence, do not eat Common Bean with Vemurafenib treatment for this cancer. (Haripaul Sharma et al, PLoS One., 2014; Yuka Kimura et al, Food Chem Toxicol., 2010; Weijiang Zhang et al, Clin Pharmacokinet., 2017; Eli L Diamond et al, JAMA Oncol., 2018; Elena Makino et al, Cell Death Dis., 2020; Mariam Gachechiladze et al, Int J Cancer., 2017)

Foods to Eat

Beetroot :  Beetroot contains active ingredients like Vitamin E, Beta-sitosterol, Vitamin C. Intake of Vitamin E along with Vemurafenib treatment for Erdheim Chester Disease causes a decrease  in a specific biochemical pathway which is called  RAS-RAF Signaling, and this is a very positive effect.  Beetroot hence should be eaten with Vemurafenib treatment for this cancer. (T Yano et al, Carcinogenesis., 2000; Julien Haroche et al, Blood., 2013; Eli L Diamond et al, JAMA Oncol., 2018)

Cardamom :  Cardamom contains active ingredients like D-limonene, Beta-sitosterol, Vitamin C. Intake of D-limonene along with Vemurafenib treatment for Erdheim Chester Disease causes a decrease  in a specific biochemical pathway which is called  RAS-RAF Signaling, and this is a very positive effect.  Cardamom hence should be eaten with Vemurafenib treatment for this cancer. (S C Chaudhary et al, Hum Exp Toxicol., 2012; Julien Haroche et al, Blood., 2013; Eli L Diamond et al, JAMA Oncol., 2018)

Should I take this Nutritional Supplement for Erdheim Chester Disease?

Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP3A4 interactions with Vemurafenib treatment, and hence should not be used. Also, Black Seed supplement interferes with the impact of Vemurafenib in Erdheim Chester Disease by increasing specific biological processes like DNA Repair. (Ahmed A Albassam et al, Saudi Pharm J., 2018; Weijiang Zhang et al, Clin Pharmacokinet., 2017)

Top 10 Foods and Supplements to Avoid for Cancer

Go beyond same nutrition guidelines for everyone and make personalized decisions with confidence.

What are the Symptoms of Erdheim Chester Disease?

The signs and symptoms of  Erdheim Chester Disease may vary based on the location of the cancer. Following are some of the signs and symptoms that may be caused by Erdheim Chester Disease.

  • Bone pain, if long bones of the legs are affected
  • Soft, fatty bumps on the eyelids, if tissues around the eyes are affected
  • Pulmonary fibrosis, if lungs are affected
  • Diabetes, if pituitary gland is affected
  • Neurological problems, if brain is affected
  • Weight loss
  • Joint pain
  • Muscle pain
  • Fever
  • Weakness

Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Erdheim Chester Disease.

What are the Treatment Options for this Cancer?

The treatment for Erdheim Chester Disease may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for Erdheim Chester Disease include:

  • Surgery
  • Radiation
  • Chemotherapy
  • Immunotherapy
  • Anti-inflammatory drugs like corticosteroids

As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Erdheim Chester Disease.

Nutrition while on Chemotherapy | Personalized to Individual's Cancer type, Lifestyle & Genetics

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Erdheim Chester Disease.

“What should I eat?” is the most frequently asked question to cancer dieticians and physicians. The right answer depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan keeps you safe from adverse nutrition interactions.

Get started NOW with answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

Top 10 Foods and Supplements to Avoid for Cancer

Go beyond same nutrition guidelines for everyone and make personalized decisions with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.