Foods for Male Breast Cancer!

Introduction

Foods for Male Breast Cancer should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

For Male Breast Cancer does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Male Breast Cancer does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Male Breast Cancer?

For example does it matter if vegetable Cabbage is consumed more compared to Broccoli? Does it make any difference if fruit Grapefruit is preferred over European Cranberry? Also if similar choices are made for nuts/seeds like Butternut over European Chestnut and for pulses like Black-eyed Pea over Lima Bean. And if what I eat matters – then how does one identify foods which are recommended for Male Breast Cancer and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Male Breast Cancer!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Grapefruit contains active ingredients Catechol, Delphinidin, Hesperetin, Curcumin, Formononetin. And European Cranberry contains active ingredients Quercetin, Ellagic Acid, Catechol, Apigenin, Delphinidin and possibly others.

A common mistake made when deciding and choosing foods to eat for Male Breast Cancer – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Male Breast Cancer.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Male Breast Cancer?

Personalized nutrition for cancers like Male Breast Cancer consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Male Breast Cancer biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Male Breast Cancer

All cancers like Male Breast Cancer can be characterized by a unique set of biochemical pathways – the signature pathways of Male Breast Cancer. Biochemical pathways like RAS-RAF Signaling, Growth Factor Signaling, PI3K-AKT-MTOR Signaling, MAPK Signaling are part of the signature definition of Male Breast Cancer. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Male Breast Cancer need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Male Breast Cancer when taking cancer treatment Trastuzumab, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

PIK3CA, GATA3, SPEN, MAP3K1 and TP53 are the top ranked reported genes for Male Breast Cancer. PIK3CA is reported in 20.3 % of the representative patients across all clinical trials. And GATA3 is reported in 15.3 %. The combined population patient data cover ages from to . % of the patient data are identified as men. The Male Breast Cancer biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Male Breast Cancer

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable CABBAGE or BROCCOLI?

Vegetable Cabbage contains many active ingredients or bioactives such as Quercetin, Catechol, Apigenin, Delphinidin, Curcumin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Adherens junction, Inositol Phosphate Signaling and MYC Signaling and others. Cabbage is recommended for Male Breast Cancer when ongoing cancer treatment is Trastuzumab. This is because Cabbage modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Trastuzumab.

Some of the active ingredients or bioactives in vegetable Broccoli are Quercetin, Resveratrol, Catechol, Delphinidin, Curcumin. These active ingredients manipulate various biochemical pathways like TGFB Signaling and Extracellular Matrix Remodelling and others. Broccoli is not recommended for Male Breast Cancer when ongoing cancer treatment is Trastuzumab because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE CABBAGE IS RECOMMENDED OVER BROCCOLI FOR Male Breast Cancer AND TREATMENT Trastuzumab.

Choose Fruit EUROPEAN CRANBERRY or GRAPEFRUIT?

Fruit European Cranberry contains many active ingredients or bioactives such as Quercetin, Ellagic Acid, Catechol, Apigenin, Delphinidin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, RAS-RAF Signaling, Adherens junction and PI3K-AKT-MTOR Signaling and others. European Cranberry is recommended for Male Breast Cancer when ongoing cancer treatment is Trastuzumab. This is because European Cranberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Trastuzumab.

Some of the active ingredients or bioactives in fruit Grapefruit are Catechol, Delphinidin, Hesperetin, Curcumin, Formononetin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and others. Grapefruit is not recommended for Male Breast Cancer when ongoing cancer treatment is Trastuzumab because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT EUROPEAN CRANBERRY IS RECOMMENDED OVER GRAPEFRUIT FOR Male Breast Cancer AND TREATMENT Trastuzumab.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Catechol, Apigenin, Delphinidin, Curcumin, Formononetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Hypoxia, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling and others. Butternut is recommended for Male Breast Cancer when ongoing cancer treatment is Trastuzumab. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Trastuzumab.

Some of the active ingredients or bioactives in European Chestnut are Quercetin, Ellagic Acid, Catechol, Apigenin, Delphinidin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, TGFB Signaling, Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling and others. European Chestnut is not recommended for Male Breast Cancer when ongoing cancer treatment is Trastuzumab because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Male Breast Cancer AND TREATMENT Trastuzumab.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Male Breast Cancer or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable WILD CARROT or PRAIRIE TURNIP?

Vegetable Wild Carrot contains many active ingredients or bioactives such as Apigenin, Curcumin, Quercetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, Angiogenesis, MAPK Signaling and PI3K-AKT-MTOR Signaling and others. Wild Carrot is recommended for risk of Male Breast Cancer when associated genetic risk is GATA3. This is because Wild Carrot increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Prairie Turnip are Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, DNA Repair and Insulin Signaling and others. Prairie Turnip is not recommended when risk of Male Breast Cancer when associated genetic risk is GATA3 because it increases the signature pathways of it.

VEGETABLE WILD CARROT IS RECOMMENDED OVER PRAIRIE TURNIP FOR GATA3 GENETIC RISK OF CANCER.

Choose Fruit NANCE or PUMMELO?

Fruit Nance contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, MYC Signaling, Angiogenesis and PI3K-AKT-MTOR Signaling and others. Nance is recommended for risk of Male Breast Cancer when associated genetic risk is GATA3. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Curcumin, Quercetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, DNA Repair and Insulin Signaling and others. Pummelo is not recommended when risk of Male Breast Cancer when associated genetic risk is GATA3 because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER PUMMELO FOR GATA3 GENETIC RISK OF CANCER.

Choose Nut COMMON WALNUT or FLAXSEED?

Common Walnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Ellagic Acid, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Insulin Signaling and PI3K-AKT-MTOR Signaling and others. Common Walnut is recommended for risk of Male Breast Cancer when associated genetic risk is GATA3. This is because Common Walnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Flaxseed are Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Insulin Signaling and PI3K-AKT-MTOR Signaling and others. Flaxseed is not recommended when risk of Male Breast Cancer when associated genetic risk is GATA3 because it increases the signature pathways of it.

COMMON WALNUT IS RECOMMENDED OVER FLAXSEED FOR GATA3 GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Male Breast Cancer. Male Breast Cancer patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Male Breast Cancer, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Cabbage contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Male Breast Cancer?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

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