No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Choriocarcinoma needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Allspice and Almond should be eaten when undergoing Methotrexate treatment for Choriocarcinoma. On the same lines, foods like Lard and Tallow should be avoided with treatment of Methotrexate for Choriocarcinoma. Vitamin B2 supplement intake does not show benefit on biochemical pathways that could improve the Methotrexate treatment efficacy in Choriocarcinoma and should be avoided.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Choriocarcinoma.
What is Choriocarcinoma?
Choriocarcinoma is a rare cancer that develops from the cells left behind after pregnancy, that normally would have become the placenta. The incidence rate of this cancer is only 2 to 7 pregnancies out of every 100,000 pregnancies per year. The non-gestational choriocarcinoma is commonly diagnosed in women who are about 40 years of age.
Choriocarcinoma has prevalence of certain genetic changes. Some of the genes such as TP53, KMT2D, PRKD1, and RRAS2 are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in Choriocarcinoma can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Choriocarcinoma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Choriocarcinoma genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Choriocarcinoma nutrition may have to be redesigned.
Why Eating Right Matters for Choriocarcinoma?
In Choriocarcinoma, activation or inhibition of some of the biochemical pathways including Wnt Betacatenin Signaling, MAPK Signaling, RAS-RAF Signaling, Myc Signaling, P53 Signaling and PI3K-AKT-MTOR Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Choriocarcinoma, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Methotrexate treatment for Choriocarcinoma
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show an example of nutrition/diet for Choriocarcinoma considering only a specific treatment- Methotrexate.
Foods to Avoid with Methotrexate treatment
Lard : Lard contains active ingredients such as Myristic Acid, Palmitic Acid and others. Saturated fatty acids like Myristic Acid interfere with the impact of Methotrexate in Choriocarcinoma by activating a specific biochemical pathway called RAS-RAF Signaling. Hence, do not eat Lard with Methotrexate treatment for Choriocarcinoma. (Jan Šrámek et al, Int J Mol Sci., 2016; Iris C Salaroglio et al, Int J Mol Sci., 2019; John H Farley et al, Obstet Gynecol., 2005)
Tallow : Tallow contains active ingredients such as Lauric Acid, Myristic Acid, Palmitic Acid and others. Lauric Acid interferes with the impact of Methotrexate in Choriocarcinoma by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, do not eat Tallow with Methotrexate treatment for Choriocarcinoma. (Jing Pu et al, J Lipid Res., 2011; David T Teachey et al, Blood., 2008; John H Farley et al, Obstet Gynecol., 2005)
Foods to Eat with Methotrexate treatment
Allspice : Allspice contains active ingredients like Salicylic Acid, Methyleugenol, Eucalyptol. Intake of Salicylic Acid along with Methotrexate treatment for Choriocarcinoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Allspice hence should be eaten with Methotrexate treatment for Choriocarcinoma. (Ronglin Jiang et al, Inflammation., 2016; David T Teachey et al, Blood., 2008; John H Farley et al, Obstet Gynecol., 2005)
Almond : Almond contains active ingredients like Salicylic Acid, Geraniin, Oleic Acid. As mentioned above, the intake of Salicylic Acid along with Methotrexate treatment for Choriocarcinoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Almond hence should be eaten with Methotrexate treatment for Choriocarcinoma. (Ronglin Jiang et al, Inflammation., 2016; David T Teachey et al, Blood., 2008; John H Farley et al, Obstet Gynecol., 2005)
Should I take this Nutritional Supplement with Methotrexate treatment?
Vitamin B2 : Vitamin B2 nutritional supplements have no known interactions with Methotrexate treatment. Also, Vitamin B2 supplement does not show benefit on other biochemical pathways that could improve the Methotrexate treatment efficacy in Choriocarcinoma.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
What are the Symptoms of Choriocarcinoma?
In the initial stages, most cancers including Choriocarcinoma may not cause any signs or symptoms. However, as the disease progresses, Choriocarcinoma may start showing symptoms.
Following are some of the signs and symptoms that may be caused by Choriocarcinoma.
- Vaginal bleeding
- Abdominal swelling
- Abdominal pain
If the cancer has spread to other parts such as lungs and brain, it may cause symptoms like:
- Difficulty in breathing
- Chest pain
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Choriocarcinoma.
What are the Treatment Options for Choriocarcinoma?
The treatment for Choriocarcinoma may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for Choriocarcinoma include:
- Surgery and chemotherapy
- SSurgery, chemotherapy, and radiation.
As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Choriocarcinoma.
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Choriocarcinoma.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.