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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Anaplastic Astrocytoma!

Jul 23, 2023

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Introduction

Foods for Anaplastic Astrocytoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Anaplastic astrocytoma is a rare and aggressive type of brain cancer that arises from the star-shaped cells called astrocytes. Pathology outlines play a critical role in defining the characteristics and features of anaplastic astrocytoma, aiding in accurate diagnosis. Radiology techniques, such as imaging tests, help visualize anaplastic astrocytoma tumors and assess their location and extent. Unfortunately, the prognosis for anaplastic astrocytoma is generally poor due to its aggressive nature. Treatment options for anaplastic astrocytoma can include surgery, radiation therapy, and chemotherapy to help manage the disease and improve the prognosis. Clinical trials offer potential new treatment options and should be considered. It is essential to recognize the symptoms of anaplastic astrocytoma, which can include headaches, seizures, cognitive difficulties, and changes in behavior. The survival rate for anaplastic astrocytoma varies and depends on several factors, including the stage of the cancer and the patient’s overall health. Proper coding using the ICD-10 system ensures accurate documentation of anaplastic astrocytoma in medical records. Understanding the prognosis and available treatment options is crucial in formulating a comprehensive treatment plan. Continuous research and advancements in chemotherapy aim to improve outcomes and increase the possibility of a cure for anaplastic astrocytoma.



For Anaplastic Astrocytoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Anaplastic Astrocytoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Anaplastic Astrocytoma?

For example does it matter if vegetable Giant Butterbur is consumed more compared to White Cabbage? Does it make any difference if fruit Pummelo is preferred over Nance? Also if similar choices are made for nuts/seeds like Butternut over Chestnut and for pulses like Adzuki Bean over Cowpea. And if what I eat matters – then how does one identify foods which are recommended for Anaplastic Astrocytoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Anaplastic Astrocytoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Anaplastic Astrocytoma can be characterized by a unique set of biochemical pathways - the signature pathways of Anaplastic Astrocytoma. Biochemical pathways like Apoptosis, MAPK Signaling, Oncogenic Cancer Epigenetics, Hypoxia are part of the signature definition of Anaplastic Astrocytoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Quercetin, Curcumin, Isoliquiritigenin, Lupeol, Phloretin. And Nance contains active ingredients Curcumin, Isoliquiritigenin, Myricetin, Lupeol, Phloretin and possibly others.

A common mistake made when deciding and choosing foods to eat for Anaplastic Astrocytoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Anaplastic Astrocytoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Anaplastic Astrocytoma?

Personalized nutrition for cancers like Anaplastic Astrocytoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Anaplastic Astrocytoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Anaplastic Astrocytoma

All cancers like Anaplastic Astrocytoma can be characterized by a unique set of biochemical pathways – the signature pathways of Anaplastic Astrocytoma. Biochemical pathways like Apoptosis, MAPK Signaling, Oncogenic Cancer Epigenetics, Hypoxia are part of the signature definition of Anaplastic Astrocytoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Anaplastic Astrocytoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Anaplastic Astrocytoma when taking cancer treatment Oxaliplatin, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

DNMT3A, IDH1, ATRX, TERT and TET2 are the top ranked reported genes for Anaplastic Astrocytoma. DNMT3A is reported in 21.9 % of the representative patients across all clinical trials. And IDH1 is reported in 14.6 %. The combined population patient data cover ages from 1 to 94. 60.9 % of the patient data are identified as men. The Anaplastic Astrocytoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Anaplastic Astrocytoma!

Food and Supplements for Anaplastic Astrocytoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable GIANT BUTTERBUR or WHITE CABBAGE?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Isoliquiritigenin, Myricetin, Lupeol, Phloretin. These active ingredients manipulate various biochemical pathways like JAK-STAT Signaling, NFKB Signaling, Cell Cycle and Epithelial to Mesenchymal Transition and others. Giant Butterbur is recommended for Anaplastic Astrocytoma when ongoing cancer treatment is Oxaliplatin. This is because Giant Butterbur modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Oxaliplatin.

Some of the active ingredients or bioactives in vegetable White Cabbage are Quercetin, Curcumin, Isoliquiritigenin, Lupeol, Phloretin. These active ingredients manipulate various biochemical pathways like Oxidative Stress and others. White Cabbage is not recommended for Anaplastic Astrocytoma when ongoing cancer treatment is Oxaliplatin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER WHITE CABBAGE FOR Anaplastic Astrocytoma AND TREATMENT Oxaliplatin.

Choose Fruit NANCE or PUMMELO?

Fruit Nance contains many active ingredients or bioactives such as Curcumin, Isoliquiritigenin, Myricetin, Lupeol, Phloretin. These active ingredients manipulate various biochemical pathways like JAK-STAT Signaling, NFKB Signaling, Cell Cycle and Epithelial to Mesenchymal Transition and others. Nance is recommended for Anaplastic Astrocytoma when ongoing cancer treatment is Oxaliplatin. This is because Nance modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Oxaliplatin.

Some of the active ingredients or bioactives in fruit Pummelo are Quercetin, Curcumin, Isoliquiritigenin, Lupeol, Phloretin. These active ingredients manipulate various biochemical pathways like Oxidative Stress and others. Pummelo is not recommended for Anaplastic Astrocytoma when ongoing cancer treatment is Oxaliplatin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT NANCE IS RECOMMENDED OVER PUMMELO FOR Anaplastic Astrocytoma AND TREATMENT Oxaliplatin.

Choose Nut BUTTERNUT or CHESTNUT?

Butternut contains many active ingredients or bioactives such as Curcumin, Isoliquiritigenin, Myricetin, Lupeol, Phloretin. These active ingredients manipulate various biochemical pathways like NFKB Signaling, JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and Cell Cycle and others. Butternut is recommended for Anaplastic Astrocytoma when ongoing cancer treatment is Oxaliplatin. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Oxaliplatin.

Some of the active ingredients or bioactives in Chestnut are Ellagic Acid, Curcumin, Isoliquiritigenin, Myricetin, Lupeol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, Oxidative Stress and Epithelial to Mesenchymal Transition and others. Chestnut is not recommended for Anaplastic Astrocytoma when ongoing cancer treatment is Oxaliplatin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER CHESTNUT FOR Anaplastic Astrocytoma AND TREATMENT Oxaliplatin.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Anaplastic Astrocytoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable CAULIFLOWER or AMERICAN POKEWEED?

Vegetable Cauliflower contains many active ingredients or bioactives such as Curcumin, Formononetin, Lupeol, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Angiogenesis, JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and P53 Signaling and others. Cauliflower is recommended for risk of Anaplastic Astrocytoma when associated genetic risk is ATRX. This is because Cauliflower increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable American Pokeweed are Apigenin, Curcumin, Quercetin, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like DNA Repair and others. American Pokeweed is not recommended when risk of Anaplastic Astrocytoma when associated genetic risk is ATRX because it increases the signature pathways of it.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER AMERICAN POKEWEED FOR ATRX GENETIC RISK OF CANCER.

Choose Fruit RED RASPBERRY or ACEROLA?

Fruit Red Raspberry contains many active ingredients or bioactives such as Curcumin, Quercetin, Ellagic Acid, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, Hypoxia and P53 Signaling and others. Red Raspberry is recommended for risk of Anaplastic Astrocytoma when associated genetic risk is ATRX. This is because Red Raspberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Acerola are Apigenin, Curcumin, Quercetin, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and DNA Repair and others. Acerola is not recommended when risk of Anaplastic Astrocytoma when associated genetic risk is ATRX because it increases the signature pathways of it.

FRUIT RED RASPBERRY IS RECOMMENDED OVER ACEROLA FOR ATRX GENETIC RISK OF CANCER.

Choose Nut COMMON WALNUT or FLAXSEED?

Common Walnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Ellagic Acid, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like Angiogenesis, JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and Apoptosis and others. Common Walnut is recommended for risk of Anaplastic Astrocytoma when associated genetic risk is ATRX. This is because Common Walnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Flaxseed are Apigenin, Curcumin, Formononetin, Lupeol, Myricetin. These active ingredients manipulate various biochemical pathways like Angiogenesis, JAK-STAT Signaling and DNA Repair and others. Flaxseed is not recommended when risk of Anaplastic Astrocytoma when associated genetic risk is ATRX because it increases the signature pathways of it.

COMMON WALNUT IS RECOMMENDED OVER FLAXSEED FOR ATRX GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Anaplastic Astrocytoma. Anaplastic Astrocytoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Anaplastic Astrocytoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Giant Butterbur contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Anaplastic Astrocytoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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