No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Anaplastic Astrocytoma needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Sweet Potato and Cucumber should be eaten when undergoing Capecitabine treatment for Anaplastic Astrocytoma. On the other hand, for Anaplastic Astrocytoma, Wild Leek and Mulberry should be eaten with treatment of Oxaliplatin. On the same lines, foods like Coriander and Common Bean should be avoided with treatment of Capecitabine for Anaplastic Astrocytoma.. If the treatment is Oxaliplatin, then avoid Currant and Corn.
Black Seed supplements have no known adverse interactions with Capecitabine treatment. Hence, Black seed supplements can be eaten when undergoing Capecitabine treatment for Anaplastic Astrocytoma. Similarly, Curcumin can be eaten with treatment of Oxaliplatin.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Anaplastic Astrocytoma.
What is Anaplastic Astrocytoma?
Anaplastic Astrocytoma is a rare brain tumor, which comes under Grade III astrocytoma that develops from brain cells called astrocytes. The incidence rate of this cancer is only 0.37 per 1 lakh people per year. This cancer is commonly diagnosed in people who are about 54 years of age, however, it can occur in people of any age. It is more commonly found in men as compared to women.
Anaplastic Astrocytoma has prevalence of certain genetic changes. Some of the genes such as TP53, IDH1, ATRX, and TERT are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in Anaplastic Astrocytoma can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Anaplastic Astrocytoma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Anaplastic Astrocytoma genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Anaplastic Astrocytoma nutrition may have to be redesigned.
Why Eating Right Matters for Anaplastic Astrocytoma?
In Anaplastic Astrocytoma, activation or inhibition of some of the biochemical pathways including Runx Signaling, Cancer Epigenetics, MAPK Signaling, Apoptosis, Nfkb Signaling, Dna Repair, Cell Cycle, Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling, Oxidative Stress, JAK-STAT Signaling, Post Translational Modification, Epithelial To Mesenchymal Transition, Extracellular Matrix Remodelling and C-type Lectin Receptor Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Anaplastic Astrocytoma, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Capecitabine treatment for Anaplastic Astrocytoma
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show changes in nutrition/diet for Anaplastic Astrocytoma considering only the treatment changes.
Foods to Avoid with Capecitabine treatment
Coriander and Common Bean: Coriander and Common Bean contains active ingredients such as Apigenin, Gallic Acid, Linalool and others. Apigenin interferes with the impact of Capecitabine in Anaplastic Astrocytoma by activating a specific biological process called DNA Repair. Hence, do not eat Coriander and Common Bean with Capecitabine treatment for this cancer. (Haripaul Sharma et al, PLoS One., 2014; M D Wyatt et al, Cell Mol Life Sci. 2009, Juliana Ferreira de Sousa et al, Genet Mol Biol., 2019)
Foods to Eat with Capecitabine treatment
Sweet Potato and Cucumber : Sweet Potato and Cucumber contains active ingredients like Salicylic Acid and Linoleic Acid. Intake of Salicylic Acid along with Capecitabine treatment for Anaplastic Astrocytoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Sweet Potato and Cucumber hence should be eaten with Capecitabine treatment for this cancer. (Jinbo Fu et al, Sci Rep., 2019; Daniel K Broderick et al, Cancer Res., 2004; Zhihang Chen et al, Mol Med., 2020; Riccardo Giampieri et al, Clin Colorectal Cancer., 2017; Erika F Rodriguez et al, Acta Neuropathol., 2011)
Should I take this Nutritional Supplement with Capecitabine treatment?
Black Seed : Black Seed nutritional supplements contain active ingredients like Carvacrol and Thymoquinone which have no known reported CYP (drug metabolizing enzyme) interactions with Capecitabine treatment. Black Seed supports the Capecitabine treatment for Anaplastic Astrocytoma by decreasing specific biochemical pathways called MAPK Signaling, NFKB Signaling, PI3K-AKT-MTOR Signaling, DNA Repair. (Yun Luo et al, Oxid Med Cell Longe., 2016; Zhenlan Li et al, Inflammation., 2016; Resham Lal Gurung et al, PLoS One., 2010; Erika F Rodriguez et al, Acta Neuropathol., 2011)
Example Foods to “Not Eat” and Eat with Oxaliplatin treatment for Anaplastic Astrocytoma
Foods to Avoid with Oxaliplatin treatment
Currant : Currant contains active ingredients such as Caffeic Acid, Gallic Acid, Citric Acid and others. Caffeic Acid interferes with the impact of Oxaliplatin in Anaplastic Astrocytoma by blocking a specific biological process called Post Translational Modification. Hence, do not eat Currant with Oxaliplatin treatment for Anaplastic Astrocytoma. (M Huncharek et al, Cancer Treat Rev., 1998)
Corn : Corn contains active ingredients such as Aescin, Gallic Acid, Oleic Acid and others. Aescin interferes with the impact of Oxaliplatin in Anaplastic Astrocytoma by activating a specific biological process called Cell Cycle. Hence, do not eat Corn with Oxaliplatin treatment for Anaplastic Astrocytoma. (Sara William-Faltaos et al, Fundam Clin Pharmacol., 2007; M Huncharek et al, Cancer Treat Rev., 1998)
Foods to Eat with Oxaliplatin treatment
Wild Leek : Wild Leek contains active ingredients like Vitamin C, Retinol and others. Intake of Vitamin C along with Oxaliplatin treatment for Anaplastic Astrocytoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Wild Leek hence should be eaten with Oxaliplatin treatment for this cancer. (Lin Zhao et al, Mol Med Rep., 2020; Siru Zhou et al, Neuroepidemiology., 2015; Erika F Rodriguez et al, Acta Neuropathol., 2011)
Mulberry : Mulberry contains active ingredients like Morusin, Deoxynojirimycin and Moracin P. Intake of Morusin along with Oxaliplatin treatment for Anaplastic Astrocytoma causes a decrease in a specific biochemical pathway which is called DNA Repair, and this is a very positive effect. Mulberry hence should be eaten with Oxaliplatin treatment for Anaplastic Astrocytoma. (Feng Wang et al, Oncotarget., 2017; Camilla Trovesi et al, J Mol Biol., 2013; M Huncharek et al, Cancer Treat Rev., 1998)
Should I take this Nutritional Supplement with Oxaliplatin treatment?
Curcumin : Curcumin has no known reported CYP (drug metabolizing enzyme) interactions with Oxaliplatin treatment. Curcumin supports the Oxaliplatin treatment for Anaplastic Astrocytoma by decreasing the biochemical pathway(s) called C-type Lectin Receptor Signaling, Extracellular Matrix Remodelling, Epithelial to Mesenchymal Transition, MAPK Signaling, JAK-STAT Signaling, Cell Cycle, NFKB Signaling, PI3K-AKT-MTOR Signaling and increasing pathways like Apoptosis, Oxidative Stress, RUNX Signaling. (Jiahuan Yin et al, Onco Targets Ther., 2019; Mirna A Romero-Hernández et al, Toxicol Mech Methods., 2013)
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
What are the Symptoms of Anaplastic Astrocytoma?
In the initial stages, most cancers including Anaplastic Astrocytoma may not cause any signs or symptoms. However, as the disease progresses, it may start showing symptoms.
Following are some of the signs and symptoms that may be caused by Anaplastic Astrocytoma.
- Headache in the morning
- Changes in behavior
- Motor dysfunction
- Neuroendocrine abnormalities
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Anaplastic Astrocytoma.
What are the Treatment Options for Anaplastic Astrocytoma?
The treatment for Anaplastic Astrocytoma may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back.
The treatment options for Anaplastic Astrocytoma include:
As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Anaplastic Astrocytoma.
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Anaplastic Astrocytoma.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.