Foods for Malignant Fibrous Histiocytoma!

Introduction

Foods for Malignant Fibrous Histiocytoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Malignant fibrous histiocytoma (MFH) is also called undifferentiated pleomorphic sarcoma (UPS) or malignant fibrous cytoma, and it is the most common soft tissue sarcoma of late adult life. Malignant fibrous histiocytoma are aggressive tumors that often grow quickly and spread to other parts of the body, including the lung. This is a cancer that originates in the soft tissue that includes muscles, nerves, blood vessels, fats, fibrous tissues (tendons, ligaments, and cartilage), skin, or bone. Malignant fibrous histiocytoma can occur anywhere in the body, but more commonly occurs in the legs (50% of cases in the thighs), arms or back of the abdomen. MFH usually occurs in older adults with a predominance in males and may sometimes occur as a second cancer in patients who had retinoblastoma. Symptoms are usually a painless, enlarging palpable mass while other symptoms may be caused locally depending on the location of the tumor. Malignant fibrous histiocytoma treatment usually includes aggressive resection (surgical removal of the entirety of the tumor). Supplementary adjuvant chemotherapy and radiotherapy are useful in reducing local recurrence rate. Favorable prognostic factors for malignant fibrous histiocytoma include small tumor size, low grade, extremity location, superficial location, and localized disease. In addition, supportive care with the right nutrition (foods and natural supplements) can help improve patients’ well-being.

For Malignant Fibrous Histiocytoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Malignant Fibrous Histiocytoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Malignant Fibrous Histiocytoma?

For example does it matter if vegetable Globe Artichoke is consumed more compared to Kohlrabi? Does it make any difference if fruit Pummelo is preferred over Breadfruit? Also if similar choices are made for nuts/seeds like Butternut over Cashew Nut and for pulses like Broad Bean over Lima Bean. And if what I eat matters – then how does one identify foods which are recommended for Malignant Fibrous Histiocytoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Malignant Fibrous Histiocytoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Quercetin, Apigenin, Curcumin, Genistein, Formononetin. And Breadfruit contains active ingredients Quercetin, Apigenin, Curcumin, Genistein, Formononetin and possibly others.

A common mistake made when deciding and choosing foods to eat for Malignant Fibrous Histiocytoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Malignant Fibrous Histiocytoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Malignant Fibrous Histiocytoma?

Personalized nutrition for cancers like Malignant Fibrous Histiocytoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Malignant Fibrous Histiocytoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Malignant Fibrous Histiocytoma

All cancers like Malignant Fibrous Histiocytoma can be characterized by a unique set of biochemical pathways – the signature pathways of Malignant Fibrous Histiocytoma. Biochemical pathways like RAS-RAF Signaling, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints, MAPK Signaling are part of the signature definition of Malignant Fibrous Histiocytoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Malignant Fibrous Histiocytoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Malignant Fibrous Histiocytoma when taking cancer treatment Everolimus, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

TP53, ATRX, RB1, TERT and KMT2D are the top ranked reported genes for Malignant Fibrous Histiocytoma. TP53 is reported in 14.4 % of the representative patients across all clinical trials. And ATRX is reported in 4.6 %. The combined population patient data cover ages from 29 to 90. 54.0 % of the patient data are identified as men. The Malignant Fibrous Histiocytoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Malignant Fibrous Histiocytoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable GLOBE ARTICHOKE or KOHLRABI?

Vegetable Globe Artichoke contains many active ingredients or bioactives such as Apigenin, Curcumin, Genistein, Formononetin, Phloretin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Cell Cycle, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling and others. Globe Artichoke is recommended for Malignant Fibrous Histiocytoma when ongoing cancer treatment is Everolimus. This is because Globe Artichoke modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Everolimus.

Some of the active ingredients or bioactives in vegetable Kohlrabi are Quercetin, Curcumin, Genistein, Formononetin, Phloretin. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling and WNT Beta Catenin Signaling and others. Kohlrabi is not recommended for Malignant Fibrous Histiocytoma when ongoing cancer treatment is Everolimus because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE GLOBE ARTICHOKE IS RECOMMENDED OVER KOHLRABI FOR Malignant Fibrous Histiocytoma AND TREATMENT Everolimus.

Choose Fruit BREADFRUIT or PUMMELO?

Fruit Breadfruit contains many active ingredients or bioactives such as Quercetin, Apigenin, Curcumin, Genistein, Formononetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Microtubule Dynamics, Oncogenic Cancer Epigenetics and Cell Survival and others. Breadfruit is recommended for Malignant Fibrous Histiocytoma when ongoing cancer treatment is Everolimus. This is because Breadfruit modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Everolimus.

Some of the active ingredients or bioactives in fruit Pummelo are Quercetin, Apigenin, Curcumin, Genistein, Formononetin. These active ingredients manipulate various biochemical pathways like Microtubule Dynamics, WNT Beta Catenin Signaling, RAS-RAF Signaling and Epithelial to Mesenchymal Transition and others. Pummelo is not recommended for Malignant Fibrous Histiocytoma when ongoing cancer treatment is Everolimus because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT BREADFRUIT IS RECOMMENDED OVER PUMMELO FOR Malignant Fibrous Histiocytoma AND TREATMENT Everolimus.

Choose Nut BUTTERNUT or CASHEW NUT?

Butternut contains many active ingredients or bioactives such as Apigenin, Curcumin, Genistein, Formononetin, Lycopene. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Glucocorticoid Signaling, Microtubule Dynamics and Oxidative Stress and others. Butternut is recommended for Malignant Fibrous Histiocytoma when ongoing cancer treatment is Everolimus. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Everolimus.

Some of the active ingredients or bioactives in Cashew Nut are Quercetin, Curcumin, Formononetin, Phloretin, Lupeol. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling, PI3K-AKT-MTOR Signaling, MAPK Signaling and Oxidative Stress and others. Cashew Nut is not recommended for Malignant Fibrous Histiocytoma when ongoing cancer treatment is Everolimus because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER CASHEW NUT FOR Malignant Fibrous Histiocytoma AND TREATMENT Everolimus.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Malignant Fibrous Histiocytoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or SHALLOT?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair, MYC Signaling, Stem Cell Signaling and PI3K-AKT-MTOR Signaling and others. Giant Butterbur is recommended for risk of Malignant Fibrous Histiocytoma when associated genetic risk is ATRX. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Shallot are Apigenin, Curcumin, Lupeol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like Oncogenic Cancer Epigenetics and Stem Cell Signaling and others. Shallot is not recommended when risk of Malignant Fibrous Histiocytoma when associated genetic risk is ATRX because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER SHALLOT FOR ATRX GENETIC RISK OF CANCER.

Choose Fruit JAVA PLUM or STAR FRUIT?

Fruit Java Plum contains many active ingredients or bioactives such as Apigenin, Curcumin, Ellagic Acid, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, DNA Repair, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Java Plum is recommended for risk of Malignant Fibrous Histiocytoma when associated genetic risk is ATRX. This is because Java Plum increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Star Fruit are Apigenin, Curcumin, Lupeol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like Oncogenic Cancer Epigenetics and Stem Cell Signaling and others. Star Fruit is not recommended when risk of Malignant Fibrous Histiocytoma when associated genetic risk is ATRX because it increases the signature pathways of it.

FRUIT JAVA PLUM IS RECOMMENDED OVER STAR FRUIT FOR ATRX GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or EUROPEAN CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Lupeol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair, MYC Signaling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling and others. Common Hazelnut is recommended for risk of Malignant Fibrous Histiocytoma when associated genetic risk is ATRX. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in European Chestnut are Apigenin, Curcumin, Quercetin, Ellagic Acid, Lupeol. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling and others. European Chestnut is not recommended when risk of Malignant Fibrous Histiocytoma when associated genetic risk is ATRX because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR ATRX GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Malignant Fibrous Histiocytoma. Malignant Fibrous Histiocytoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Malignant Fibrous Histiocytoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Globe Artichoke contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Malignant Fibrous Histiocytoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

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• https://my.clevelandclinic.org/health/diseases/22435-undifferentiated-pleomorphic-sarcoma;
• https://healthjade.net/malignant-fibrous-histiocytoma/;
• https://www.webmd.com/cancer/malignant-fibrous-histiocytoma-of-bone )