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What should I Eat?

is the most common question asked by cancer patients.
Choose food and nutritional supplements which reduces adverse interactions with your cancer treatment and support them.

is the most common question asked by cancer patients. Choose food and nutritional supplements which reduces adverse interactions with your cancer treatment and support them.

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Get your personalized nutrition plan for cancer at

Which 3 Foods to Avoid for Malignant Fibrous Histiocytoma?

Mar 19, 2021

Highlights

No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Malignant Fibrous Histiocytoma needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.

Foods like Turnip and Asparagus should be eaten when undergoing Everolimus treatment for Malignant Fibrous Histiocytoma. On the other hand, for this cancer, Rosemary and Barley should be eaten with treatment of Octreotide. On the same lines, foods like Amaranth and Beetroot should be avoided with treatment of Everolimus for Malignant Fibrous Histiocytoma. If the treatment is Octreotide, then avoid Radish and Spinach.

Black Seed contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Everolimus and Octreotide treatments for this cancer and hence should be avoided.

You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Malignant Fibrous Histiocytoma.



What is Malignant Fibrous Histiocytoma?

Malignant Fibrous Histiocytoma is a rare soft tissue sarcoma that develops from the soft tissue such as muscles and tendons and sometimes in bones. The incidence rate of this cancer is only 0.88 per 1 lakh people per year. This cancer is commonly diagnosed in people who are about 60-70  years of age, however, it can occur in people of any age. It accounts for 20%–30% of all soft-tissue sarcomas. It is more commonly found in Caucasians as compared to African Americans.

Malignant Fibrous Histiocytoma - Symptoms, Diet, treatment, Foods

Malignant Fibrous Histiocytoma has prevalence of certain genetic changes. Some of the genes such as TP53, CHD1, COL2A1, and DCC are known to have genetic abnormalities in this cancer resulting in a change of function. 

The genetic abnormalities found in Malignant Fibrous Histiocytoma can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment.  In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for this cancer. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Malignant Fibrous Histiocytoma genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for this cancer may have to be redesigned.

Why Eating Right Matters for Malignant Fibrous Histiocytoma?

In Malignant Fibrous Histiocytoma, activation or inhibition of some of the biochemical pathways including Growth Factor Signaling, Angiogenesis, PI3K-AKT-MTOR Signaling, Cancer Epigenetics, Nutrient Sensing, Cell Cycle and MAPK Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of this cancer, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.

Example Foods to “Not Eat” and Eat with Everolimus treatment

The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show changes in nutrition/diet for Malignant Fibrous Histiocytoma considering only the treatment changes.

Foods to Avoid

Amaranth and Beetroot: Amaranth and Beetroot contains active ingredients such as Beta-sitosterol, Linoleic Acid, Linolenic Acid and others. Beta-sitosterol interferes with the impact of Everolimus in Malignant Fibrous Histiocytoma by activating a specific biological process called Nutrient sensing via modulators like mTOR Complexes and AMPK. Hence, do not eat Amaranth and Beetroot with Everolimus treatment for Malignant Fibrous Histiocytoma. (Seung-Lark Hwang et al, Biochem Biophys Res Commun., 2008; Mio Harachi et al, Int J Mol Sci., 2018; María Gutiérrez-Salmerón et al, PLoS Biol., 2020; J-Y Blay et al, Ann Oncol., 2011; Xiongfei Li et al, J Thorac Dis., 2017)

Foods to Eat

Turnip :  Turnip contains active ingredients like Indole-3-carbinol, Retinol and Sulforaphane. Intake of Indole-3-carbinol along with Everolimus treatment for Malignant Fibrous Histiocytoma causes a decrease  in a specific biochemical pathway which is called  PI3K-AKT-MTOR Signaling, and this is a very positive effect.  Turnip hence should be eaten with Everolimus treatment for Malignant Fibrous Histiocytoma. (Ada Popolo et al, Semin Cancer Biol., 2017; Taofeek K Owonikoko et al, Am Soc Clin Oncol Educ Book., 2013; J-Y Blay et al, Ann Oncol., 2011; Xiongfei Li et al, J Thorac Dis., 2017)

Asparagus :  Asparagus contains active ingredients like Rutin, Kaempferol, and others. Intake of Rutin along with Everolimus treatment for Malignant Fibrous Histiocytoma causes a decrease  in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect.  Asparagus hence should be eaten with Everolimus treatment for Malignant Fibrous Histiocytoma. (Bin Zhao et al, Arch Oral Biol., 2020; J-Y Blay et al, Ann Oncol., 2011; Xiongfei Li et al, J Thorac Dis., 2017)

Should I take this Nutritional Supplement for Malignant Fibrous Histiocytoma?

Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP3A4 interactions with Everolimus treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Everolimus treatment efficacy in Malignant Fibrous Histiocytoma. Hence, do not take Black Seed supplements with Everolimus treatment for Malignant Fibrous Histiocytoma. (Ahmed A Albassam et al, Saudi Pharm J., 2018; David N Franz et al, Epilepsia., 2018;  Xiongfei Li et al, J Thorac Dis., 2017) 

Example Foods to “Not Eat” and Eat with Octreotide treatment

Foods to Avoid

Radish : Radish contains active ingredients such as Linoleic Acid, Isorhamnetin, Linolenic Acid and others. Linoleic Acid interferes with the impact of Octreotide in Malignant Fibrous Histiocytoma by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, do not eat Radish with Octreotide treatment for this cancer. (Bernhard Hennig et al, J Nutr Biochem., 2006; Caitlin D May et al, Cancer Biol Ther., 2017; Corinne Bousquet et al, J Clin Endocrinol Metab., 2012; Tullio Florio et al, Anticancer Res., May-Jun 2003)

Spinach : Spinach contains active ingredients such as Apigenin, Kaempferol and  Linoleic Acid. As mentioned above, Linoleic Acid  interferes with the impact of Octreotide in Malignant Fibrous Histiocytoma by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, do not eat Spinach with Octreotide treatment for this cancer. (Bernhard Hennig et al, J Nutr Biochem., 2006; Caitlin D May et al, Cancer Biol Ther., 2017; Corinne Bousquet et al, J Clin Endocrinol Metab., 2012; Tullio Florio et al, Anticancer Res., May-Jun 2003)

Foods to Eat

Rosemary :  Rosemary contains active ingredients like Lupeol, Linalool and Eucalyptol. Intake of Lupeol along with Octreotide treatment for Malignant Fibrous Histiocytoma causes a decrease  in a specific biochemical pathway which is called Cell Cycle, and this is a very positive effect.  Rosemary hence should be eaten with Octreotide treatment for this cancer. (Nupoor Prasad et al, J Biosci., 2018; Marily Theodoropoulou et al, Cancer Res., 2006; Tullio Florio et al, Anticancer Res., May-Jun 2003)

Barley :  Barley contains active ingredients like Esculin, Vitamin C and Oleic Acid. Intake of Esculin along with Octreotide treatment for Malignant Fibrous Histiocytoma causes a decrease in a biological process which is called Cancer Proliferation, and this is a very positive effect. Barley hence should be eaten with Octreotide treatment for this cancer. (M Mo et al, Zhonghua Zhong Liu Za Zhi., 2020; Hai-lin Liu et al, Acta Pharmacol Sin., 2004; Tullio Florio et al, Anticancer Res., May-Jun 2003)

Should I take this Nutritional Supplement for Malignant Fibrous Histiocytoma?

Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP3A4 interactions with Octreotide treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Octreotide treatment efficacy in Malignant Fibrous Histiocytoma. (Ahmed A Albassam et al, Saudi Pharm J., 2018; Xiaoyu Sun et al, BMC Gastroenterol., 2021; Tullio Florio et al, Anticancer Res., May-Jun 2003)

Top 10 Foods and Supplements to Avoid for Cancer

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What are the Symptoms of Malignant Fibrous Histiocytoma?

In the initial stages, most cancers including Malignant Fibrous Histiocytoma may not cause any signs or symptoms. However, as the disease progresses, Malignant Fibrous Histiocytoma may start showing symptoms. 

Following are some of the signs and symptoms that may be caused by Malignant Fibrous Histiocytoma.

  • Swelling in the joints or over a bone
  • Pain at the site of cancer
  • Lump (can be painless)
  • Unexplained Bone fractures

Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Malignant Fibrous Histiocytoma.

What are the Treatment Options for this Cancer?

The treatment for Malignant Fibrous Histiocytoma may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for Malignant Fibrous Histiocytoma include:

  • Surgery 
  • Radiotherapy
  • Chemotherapy
  • Palliative Care

As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Malignant Fibrous Histiocytoma.

Palliative Care Nutrition for Cancer | When Conventional Treatment is not Working

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Malignant Fibrous Histiocytoma.

“What should I eat?” is the most frequently asked question to cancer dieticians and physicians. The right answer depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan keeps you safe from adverse nutrition interactions.

Get started NOW with answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

Top 10 Foods and Supplements to Avoid for Cancer

Go beyond same nutrition guidelines for everyone and make personalized decisions with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.