Foods for Peritoneal Mesothelioma!

Introduction

Foods for Peritoneal Mesothelioma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Peritoneal Mesothelioma, a form of cancer primarily affecting the abdominal lining, is often linked to asbestos exposure as its primary cause. Its diagnosis, which requires detailed pathology outlines as per the CAP protocol, is challenging due to non-specific symptoms like abdominal pain. Radiological imaging plays a crucial role in the diagnosis and assessment of Peritoneal Mesothelioma. The ICD-10 classification aids in its systematic documentation. The prognosis of this disease varies, with life expectancy and survival rates depending on factors such as disease stage and overall health. Treatment typically includes chemotherapy, and there is a growing emphasis on clinical trials to explore new treatment avenues. Understanding the different types of Peritoneal Mesothelioma is essential for effective management, and current research focuses on improving the survival rate and quality of life for affected individuals.

For Peritoneal Mesothelioma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Peritoneal Mesothelioma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Peritoneal Mesothelioma?

For example does it matter if vegetable Cauliflower is consumed more compared to American Pokeweed? Does it make any difference if fruit Pummelo is preferred over Lemon? Also if similar choices are made for nuts/seeds like Black Walnut over European Chestnut and for pulses like Green Bean over Catjang Pea. And if what I eat matters – then how does one identify foods which are recommended for Peritoneal Mesothelioma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Peritoneal Mesothelioma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Quercetin, Protocatechuic Acid, Lycopene, Curcumin, Apigenin. And Lemon contains active ingredients D-limonene, Protocatechuic Acid, Linalool, Imperatorin, Nobiletin and possibly others.

A common mistake made when deciding and choosing foods to eat for Peritoneal Mesothelioma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Peritoneal Mesothelioma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Peritoneal Mesothelioma?

Personalized nutrition for cancers like Peritoneal Mesothelioma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Peritoneal Mesothelioma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Peritoneal Mesothelioma

All cancers like Peritoneal Mesothelioma can be characterized by a unique set of biochemical pathways – the signature pathways of Peritoneal Mesothelioma. Biochemical pathways like RAS-RAF Signaling, mRNA Splicing, Oncogenic Cancer Epigenetics, DNA Repair are part of the signature definition of Peritoneal Mesothelioma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Peritoneal Mesothelioma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Peritoneal Mesothelioma when taking cancer treatment Radiation, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

DNMT3A, TET2, PPM1D, BAP1 and ASXL1 are the top ranked reported genes for Peritoneal Mesothelioma. DNMT3A is reported in 25.3 % of the representative patients across all clinical trials. And TET2 is reported in 10.3 %. The combined population patient data cover ages from 12 to 89. 65.8 % of the patient data are identified as men. The Peritoneal Mesothelioma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Peritoneal Mesothelioma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable CAULIFLOWER or AMERICAN POKEWEED?

Vegetable Cauliflower contains many active ingredients or bioactives such as Curcumin, Formononetin, Lupeol, Isoliquiritigenin, Phloretin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, Angiogenesis, MAPK Signaling and RAS-RAF Signaling and others. Cauliflower is recommended for Peritoneal Mesothelioma when ongoing cancer treatment is Radiation. This is because Cauliflower modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in vegetable American Pokeweed are Quercetin, Protocatechuic Acid, Curcumin, Apigenin, Formononetin. These active ingredients manipulate various biochemical pathways like DNA Repair and others. American Pokeweed is not recommended for Peritoneal Mesothelioma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER AMERICAN POKEWEED FOR Peritoneal Mesothelioma AND TREATMENT Radiation.

Choose Fruit LEMON or PUMMELO?

Fruit Lemon contains many active ingredients or bioactives such as D-limonene, Protocatechuic Acid, Linalool, Imperatorin, Nobiletin. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling, Angiogenesis, MAPK Signaling and MYC Signaling and others. Lemon is recommended for Peritoneal Mesothelioma when ongoing cancer treatment is Radiation. This is because Lemon modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in fruit Pummelo are Quercetin, Protocatechuic Acid, Lycopene, Curcumin, Apigenin. These active ingredients manipulate various biochemical pathways like DNA Repair and others. Pummelo is not recommended for Peritoneal Mesothelioma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT LEMON IS RECOMMENDED OVER PUMMELO FOR Peritoneal Mesothelioma AND TREATMENT Radiation.

Choose Nut BLACK WALNUT or EUROPEAN CHESTNUT?

Black Walnut contains many active ingredients or bioactives such as Ellagic Acid, Quercetin, Protocatechuic Acid, Curcumin, Apigenin. These active ingredients manipulate various biochemical pathways like Angiogenesis, MAPK Signaling, NFKB Signaling and PI3K-AKT-MTOR Signaling and others. Black Walnut is recommended for Peritoneal Mesothelioma when ongoing cancer treatment is Radiation. This is because Black Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in European Chestnut are Ellagic Acid, Quercetin, Protocatechuic Acid, Curcumin, Apigenin. These active ingredients manipulate various biochemical pathways like DNA Repair and others. European Chestnut is not recommended for Peritoneal Mesothelioma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BLACK WALNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Peritoneal Mesothelioma AND TREATMENT Radiation.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Peritoneal Mesothelioma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or LEEK?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Apigenin, Catechol, Lupeol, Lycopene. These active ingredients manipulate various biochemical pathways like Hypoxia, P53 Signaling, Angiogenesis and PI3K-AKT-MTOR Signaling and others. Giant Butterbur is recommended for risk of Peritoneal Mesothelioma when associated genetic risk is ASXL1. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Leek are Curcumin, Apigenin, Catechol, Lupeol, Lycopene. These active ingredients manipulate various biochemical pathways like DNA Repair, Stem Cell Signaling and Cell Cycle Checkpoints and others. Leek is not recommended when risk of Peritoneal Mesothelioma when associated genetic risk is ASXL1 because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER LEEK FOR ASXL1 GENETIC RISK OF CANCER.

Choose Fruit NANCE or GRAPEFRUIT?

Fruit Nance contains many active ingredients or bioactives such as Curcumin, Apigenin, Catechol, Lupeol, Protocatechuic Acid. These active ingredients manipulate various biochemical pathways like Hypoxia, P53 Signaling and Angiogenesis and others. Nance is recommended for risk of Peritoneal Mesothelioma when associated genetic risk is ASXL1. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Grapefruit are Curcumin, Catechol, Lupeol, Lycopene, Hesperidin. These active ingredients manipulate various biochemical pathways like DNA Repair and others. Grapefruit is not recommended when risk of Peritoneal Mesothelioma when associated genetic risk is ASXL1 because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER GRAPEFRUIT FOR ASXL1 GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Catechol, Lupeol, Lycopene. These active ingredients manipulate various biochemical pathways like Hypoxia, P53 Signaling, Angiogenesis and PI3K-AKT-MTOR Signaling and others. Common Hazelnut is recommended for risk of Peritoneal Mesothelioma when associated genetic risk is ASXL1. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Curcumin, Apigenin, Catechol, Ellagic Acid, Lupeol. These active ingredients manipulate various biochemical pathways like DNA Repair and Stem Cell Signaling and others. Chestnut is not recommended when risk of Peritoneal Mesothelioma when associated genetic risk is ASXL1 because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR ASXL1 GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Peritoneal Mesothelioma. Peritoneal Mesothelioma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Peritoneal Mesothelioma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Cauliflower contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Peritoneal Mesothelioma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Msk Impact 2017
• Cancer therapy shapes the fitness landscape of clonal hematopoiesis.
• Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines.
• D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis.
• Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel.
• The antitumor effects of geraniol: Modulation of cancer hallmark pathways (Review).
• Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells.
• https://www.mesothelioma.com/mesothelioma/types/peritoneal
• https://www.mesotheliomahope.com/mesothelioma/peritoneal