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What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

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Which 3 Foods to Avoid for Granulosa Cell Tumor?

Mar 17, 2021

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Highlights

No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Granulosa Cell Tumor needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.

Foods like Asparagus and Avocado should be eaten when undergoing Radiation treatment for Granulosa Cell Tumor. On the other hand, for Granulosa Cell Tumor, Rhubarb and Elderberry should be eaten with treatment of Temozolomide. On the same lines, foods like Amaranth and Beetroot should be avoided with treatment of Radiation for Granulosa Cell Tumor.  If the treatment is Temozolomide, then avoid Bell Pepper and Chilli Pepper.

You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Granulosa Cell Tumor.



What is Granulosa Cell Tumor?

Granulosa Cell Tumor is a rare cancer that develops from the granulosa cells surrounding the eggs within the ovary. The incidence rate of this cancer is only 0.99 per 1 lakh people per year. This cancer is commonly diagnosed in people who are about 50-55 years of age, however, it can occur in people of any age. Granulosa cell tumor is extremely rare in the adult testicle.

Granulosa Cell tumor - Foods, Diet, Symptoms, Treatment

Granulosa Cell Tumor has prevalence of certain genetic changes. Some of the genes such as FOXL2, TERT, NUMA1, and KNL1 are known to have genetic abnormalities in this cancer resulting in a change of function. 

The genetic abnormalities found in Granulosa Cell Tumor can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment.  In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Granulosa Cell Tumor. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Granulosa Cell Tumor genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Granulosa Cell Tumor nutrition may have to be redesigned.

Why Eating Right Matters for Granulosa Cell Tumor?

In Granulosa Cell Tumor, activation or inhibition of some of the biochemical pathways including   PI3K-AKT-MTOR Signaling, Oxidative Stress, Epithelial to Mesenchymal Transition, ERK/MAPK Signaling, Hypoxia and RAS-RAF Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Granulosa Cell Tumor, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.

Example Foods to “Not Eat” and Eat with Radiation treatment for Granulosa Cell Tumor

The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show changes in nutrition/diet for Granulosa Cell Tumor considering only the treatment changes.

Foods to Avoid

Amaranth and Beetroot : Amaranth and Beetroot contain active ingredients such as Linoleic Acid, Linolenic Acid, Beta-sitosterol and others. Linoleic Acid interferes with the impact of Radiation in Granulosa Cell Tumor by activating a specific biochemical pathway called PI3K-AKT-MTOR. Hence, do not eat Amaranth and Beetroot with Radiation treatment for Granulosa Cell Tumor. (Nathalia Serna-Marquez et al, Med Oncol., 2017; Jiaheng Li et al, J Ovarian Res., 2018; Choan E et al, Gynecol Oncol., 2006)

Foods to Eat

Asparagus : Asparagus contains active ingredients like Isorhamnetin, Rutin and Quercetin. Intake of Isorhamnetin along with Radiation treatment for Granulosa Cell Tumor causes a decrease  in a specific biochemical pathway which is called  PI3K-AKT-MTOR Signaling, and this is a very positive effect.  Asparagus hence should be eaten with Radiation treatment for Granulosa Cell Tumor. (Shan Hu et al, Mol Med Rep., 2015; Olga C J Schuurbiers et al, J Thorac Oncol., 2009; Jiaheng Li et al, J Ovarian Res., 2018; Choan E et al, Gynecol Oncol., 2006 )

Avocado :  Avocado contains active ingredients like Beta-sitosterol, Quercetin, Estragole. Intake of Beta-sitosterol along with Radiation treatment for Granulosa Cell Tumor causes a decrease  in a specific biochemical pathway which is called  PI3K-AKT-MTOR Signaling, and this is a very positive effect.  Avocado hence should be eaten with Radiation treatment for Granulosa Cell Tumor. (Heshan Xu et al, J Agric Food Chem., 2018; Olga C J Schuurbiers et al, J Thorac Oncol., 2009; Jiaheng Li et al, J Ovarian Res., 2018; Choan E et al, Gynecol Oncol., 2006)

Should I take this Nutritional Supplement for Granulosa Cell Tumor?

Black Seed : Black Seed has no known adverse interactions with Radiation treatment. Black Seed has an active ingredient called Thymoquinone which supports the Radiation treatment for Granulosa Cell Tumor by decreasing the biochemical pathways/processes called Epithelial to Mesenchymal Transition, MAPK Signaling, JAK-STAT Signaling, NFKB Signaling, Notch Signaling, PI3K-AKT-MTOR Signaling, TGFB Signaling, RAS-RAF Signaling and increasing biological processes like Oxidative Stress. (Fabliha Ahmed Chowdhury et al, Biomed Res Int., 2018; Padma Sandeep Koka et al, Exp Biol Med (Maywood)., 2010; Jiaheng Li et al, J Ovarian Res., 2018; Choan E et al, Gynecol Oncol., 2006)

Example Foods to “Not Eat” and Eat with Temozolomide treatment for Granulosa Cell Tumor

Foods to Avoid

Bell Pepper and Chilli Pepper : Bell Pepper and Chilli Pepper contain active ingredients such as Capsaicin, Linolenic Acid, and others. Capsaicin interferes with the impact of Temozolomide in Granulosa Cell Tumor by activating a specific biochemical pathway called ERK/MAPK Signaling. Hence, do not eat Bell Pepper and Chilli Pepper with Temozolomide treatment for Granulosa Cell Tumor. (Zhi-Ye Zhuang et al, J Neurosci., 2004, Qiang Li et al, Ann Transl Med., 2020; Geraldine O’Sullivan Coyne et al, Oncotarget., 2020)

Foods to Eat

Rhubarb :  Rhubarb contains active ingredients like Sennoside B, Chrysophanol and Linolenic Acid. Intake of Sennoside B along with Temozolomide treatment for Granulosa Cell Tumor causes a decrease  in a specific biochemical pathway which is called  ERK/MAPK Signaling, and this is a very positive effect.  Rhubarb hence should be eaten with Temozolomide treatment for Granulosa Cell Tumor. (Yen-Chun Chen et al, Life Sci., 2009; Qiang Li et al, Ann Transl Med., 2020; Geraldine O’Sullivan Coyne et al, Oncotarget., 2020)

Elderberry :  Elderberry contains active ingredients like Quercetin, Betulinic Acid, Linolenic Acid and Lupeol. Intake of Quercetin along with Temozolomide treatment for Granulosa Cell Tumor causes a decrease  in a specific biochemical pathway which is called  ERK/MAPK Signaling, and this is a very positive effect.  Elderberry hence should be eaten with Temozolomide treatment for Granulosa Cell Tumor. (Rather A Rafiq et al, PLoS One., 2015; Qiang Li et al, Ann Transl Med., 2020; Geraldine O’Sullivan Coyne et al, Oncotarget., 2020)

Foods to eat and avoid for Granulosa Cell Tumor

Should I take this Nutritional Supplement for Granulosa Cell Tumor?

Black Seed : Black Seed has no known reported CYP (drug metabolizing enzyme) interactions with Temozolomide treatment. Black Seed supports the Temozolomide treatment for Granulosa Cell Tumor by decreasing the biochemical pathway(s) called MAPK Signaling, NFKB Signaling, Notch Signaling, PI3K-AKT-MTOR Signaling and increasing pathways like RUNX Signaling. (Fabliha Ahmed Chowdhury et al, Biomed Res Int., 2018; Mohammed Arif et al, Pharm Biol. 2016; Mona Pazhouhi et al, Iran J Basic Med Sci., 2016)

Which Foods To Avoid for Granulosa Cell Tumor?

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

What are the Symptoms of Granulosa Cell Tumor?

In the initial stages, most cancers including Granulosa Cell Tumor may not cause any signs or symptoms. However, as the disease progresses, Granulosa Cell Tumor may start showing symptoms. 

Following are some of the signs and symptoms that may be caused by Granulosa Cell Tumor.

  • abdominal pain
  • menstrual periods with prolonged/heavy bleeding
  • abnormal vaginal bleeding
  • irregular menstruation
  • missing period for 3 or more months in a row

Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Granulosa Cell Tumor.

What are the Treatment Options for Granulosa Cell Tumor?

The treatment for Granulosa Cell Tumor may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for Granulosa Cell Tumor include:

  • Surgery
  • Radiation therapy
  • Chemotherapy
  • Hormone therapy

Surgery or surgery followed by radiation is the most common treatment regimen for Granulosa Cell Tumor. Radiotherapy helps to shrink the tumor. The primary role of chemotherapy is in the treatment of metastatic disease. As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Granulosa Cell Tumor.

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Granulosa Cell Tumor.

“What should I eat?” is the most frequently asked question to cancer dieticians and physicians. The right answer depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan keeps you safe from adverse nutrition interactions.

Get started NOW with answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


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