No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Mycosis fungoides needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Natural Foods like Tomato and Cucumber should be eaten when undergoing Romidepsin treatment for Mycosis fungoides. On the other hand, natural foods like Bell Pepper and Margarine should be avoided with treatment of Romidepsin for Mycosis fungoides. Curcumin has CYP (drug metabolizing enzyme) interactions with Romidepsin treatment and hence should be avoided.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Mycosis fungoides.
What is Mycosis fungoides?
Mycosis fungoides is a rare cancer that develops in the T lymphocytes (white blood cells) with the abnormalities attacking the skin. The incidence rate of this cancer is only 0.5 per 1 lakh people per year. This cancer is commonly diagnosed in people who are about 58 years of age, however, it can occur in people of any age. It is commonly found in black population as compared to Asians and White population.
Mycosis fungoides has prevalence of certain genetic changes. Some of the genes such as FAT1, MGAM, KMT2D, and ROBO1 are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in Mycosis fungoides can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Mycosis fungoides. Numerous studies have consistently shown that your nutrition/diet – both natural food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Mycosis fungoides genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Mycosis fungoides nutrition may have to be redesigned.
Why Eating Right Matters for Mycosis fungoides?
In Mycosis fungoides, activation or inhibition of some of the biochemical pathways including PI3K-AKT-MTOR Signaling, MAPK Signaling, MYC Signaling and DNA Repair plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain natural foods and nutritional supplements as part of the diet may support a specific treatment of Mycosis fungoides, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Romidepsin treatment for Mycosis fungoides
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show examples of diet/nutrition (natural foods) to take and avoid for Mycosis fungoides for a specific treatment.
Foods to Avoid with Romidepsin treatment
Bell Pepper : Bell Pepper contains active ingredients such as Maltol, Capsaicin, Solasodine and others. Capsaicin interferes with the impact of Romidepsin in Mycosis fungoides due to CYP3A4 interactions and also by activating a specific biochemical pathway called MYC. Hence, do not eat Bell Pepper with Romidepsin treatment for Mycosis fungoides. (Noel Pabalan et al, J Gastrointest Cancer., 2014; Dong-Yeop Shin et al, Cancer Lett., 2015; Toshiyuki Takanohashi et al, Int J Toxicol., 2010; Eric Laille et al, J Clin Pharmacol., 2015; Lorraine Tracey et al, Blood., 2003)
Margarine : Margarine contains active ingredients such asLauric Acid, Myristic Acid, Palmitic Acid and others. Saturated fatty acids like Lauric Acid interfere with the impact of Romidepsin in Mycosis fungoides by activating a specific biochemical pathway called PI3K-AKT-MTOR. Hence, do not eat Margarine with Romidepsin treatment for Mycosis fungoides. ( (Joo Y Lee et al, J Biol Chem., 2003; Ken Saijo et al, Cancer Sci., 2012; Evangelia Papadavid et al, Exp Dermatol., 2014)
Foods to Eat with Romidepsin treatment
Tomato : Tomato contains active ingredients like Lupeol, Lutein and Citric Acid. Intake of Lupeol along with Romidepsin treatment for Mycosis fungoides causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR, and this is a very positive effect. Tomato hence should be eaten with Romidepsin treatment for Mycosis fungoides. (Lingli Zhang et al, Eur J Pharmacol., 2015; Ken Saijo et al, Cancer Sci., 2012; Evangelia Papadavid et al, Exp Dermatol., 2014)
Cucumber : Cucumber contains active ingredients like Lupeol, Cucurbitacin E and Fisetin. Intake of Lupeol along with Romidepsin treatment for Mycosis fungoides causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR, and this is a very positive effect. Cucumber hence should be eaten with Romidepsin treatment for Mycosis fungoides. (Lingli Zhang et al, Eur J Pharmacol., 2015; Ken Saijo et al, Cancer Sci., 2012; Evangelia Papadavid et al, Exp Dermatol., 2014)
Should I take this Nutritional Supplement with Romidepsin treatment?
Curcumin : Curcumin is the key ingredient in Turmeric with antioxidant properties. Curcumin nutritional supplements have CYP3A4 interactions with Romidepsin treatment, and hence should not be used. Additionally, intake of Curcumin supplement along with Romidepsin may not improve the treatment efficacy. Hence, it is better to avoid taking Curcumin supplements to stay safe while on Romidepsin treatment for Mycosis fungoides. (Takamitsu Sasaki et al, J Pharm Health Care Sci., 2017; Eric Laille et al, J Clin Pharmacol., 2015)
Are Vitamin A Supplements beneficial for patients with Mycosis Fungoides?
Researchers from Ludwig Maximilian University in Munich, Germany analyzed data from 11 Cutaneous T-cell lymphoma (CTCL) patients with mycosis fungoides who were treated with a Vitamin A derivative and found that 90.9% patients showed a marked improvement of their CTCL skin lesions with no disease progression during the treatment with the vitamin A derivative. (C Kapser et al, J Eur Acad Dermatol Venereol., 2015)
However, one should consult with their oncologist before consuming these supplements to avoid undesired interactions with ongoing treatments.
What is the Impact of Smoking and Alcohol Consumption on the Risk of Mycosis Fungoides?
Analysis of data from a European Rare Cancers Study which included a total of 76 cases of Mycosis fungoides and 2899 controls by the researchers from the University of Valencia, in Spain found that a combined exposure to high tobacco and alcohol use significantly increased the risk of Mycosis fungoides. (M M Morales Suárez-Varela et al, Eur J Cancer., 2001)
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
What are the Symptoms of Mycosis fungoides?
In the initial stages, most cancers including Mycosis fungoides may not cause any signs or symptoms. The most common symptom of mycosis fungoides is itching in the affected areas. The rash usually develops slowly, often over many years. However, as the disease progresses, it may start showing other symptoms.
Following are some of the signs and symptoms that may be caused by Mycosis fungoides.
- Scaly red rash in areas that don’t get sunlight
- Raised scaly and itchy round patches of skin
- Patches of skin with lighter color than surrounding skin
- Small Lumps that form on the skin
- Hard red plaques
- Enlarged lymph nodes
- Hair loss
- Thickening of the skin on the palms and soles
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Mycosis fungoides.
What are the Treatment Options for this cancer?
The treatment for Mycosis fungoides may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, patient’s general health and medical history. A combination of treatments are used for this cancer. The treatment options for Mycosis fungoides include:
- Radiation therapy
- Skin Ointments/creams
- Steroids and other drugs to control immune system
- Bone marrow transplantation
- Light therapy or Phototherapy
- Extracorporeal photopheresis – in which a medicine makes the cells more sensitive to light and the blood is filtered through a machine making it exposed to ultraviolet light before returning the blood to the body.
As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Mycosis fungoides.
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Mycosis fungoides.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.