No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Ampullary Carcinoma needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Bamboo and Cluster Bean should be eaten when undergoing Cisplatin treatment for Ampullary Carcinoma. On the other hand, for Ampullary Carcinoma, Lentils and Oat should be eaten with treatment of Fluorouracil. On the same lines, foods like Amaranth and Beetroot should be avoided with treatment of Cisplatin for Ampullary Carcinoma. If the treatment is Fluorouracil, then avoid Spearmint.
Black seed oil supplements contain an active ingredient called Thymoquinone. Thymoquinone is known to have CYP (drug metabolizing enzyme) interactions with Cisplatin and Fluorouracil treatments and hence should be avoided.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Ampullary Carcinoma.
What is Ampullary Carcinoma?
Ampullary Carcinoma is a rare cancer that develops in the ampulla of Vater, a small opening where the pancreatic and bile ducts connect to the first part of the small intestine. The incidence rate of this cancer is only 0.59 cases per 1 lakh per year (Daryl Ramai et al, Minerva Gastroenterol Dietol., 2019). This cancer is commonly diagnosed in people who are about 71 years of age, however, it can occur in people of any age. It is more commonly found in males as compared to females.
Ampullary Carcinoma has prevalence of certain genetic changes. Some of the genes such as TP53, KRAS, APC, and TTN are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in Ampullary Carcinoma can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Ampullary Carcinoma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Ampullary Carcinoma genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Ampullary Carcinoma nutrition may have to be redesigned.
Why Eating Right Matters for Ampullary Carcinoma?
In Ampullary Carcinoma, activation or inhibition of some of the biochemical pathways and processes including Oxidative Stress, PI3K-AKT-MTOR Signaling, Proliferation and MAPK Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Ampullary Carcinoma, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Cisplatin treatment for Ampullary Carcinoma
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show changes in nutrition/diet for Ampullary Carcinoma considering only the treatment changes.
Foods to Avoid with Cisplatin treatment
Amaranth and Beetroot : Amaranth and Beetroot contain active ingredients such as Citric Acid, Vitamin C, and others. Citric Acid interferes with the impact of Cisplatin in Ampullary Carcinoma by blocking a biological process called oxidative stress. Oxidative stress has been shown to induce apoptosis or cell death in different cancer cells. Hence, do not eat Amaranth and Beetroot with Cisplatin treatment for Ampullary Carcinoma. (Juhee Lim et al, Mol Cells., 2013; Omar M E Abdel-Salam et al, J Med Food., 2014)
Foods to Eat with Cisplatin treatment
Bamboo and Cluster Bean : Bamboo and Cluster Bean contain active ingredients like Beta-sitosterol, Vitamin C, Citric Acid and others. Intake of Beta-sitosterol along with Cisplatin treatment for Ampullary Carcinoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR and cancer proliferation, and this is a very positive effect. Bamboo and Cluster Bean hence should be eaten with Cisplatin treatment for this cancer. (Tamilselvam Rajavel et al, Sci Rep., 2018; Zhang-Qi Cao et al, Front Pharmacol., 2019; Y Zhang et al, Neoplasma., 2016; Michael J Overman et al, PLoS One,. 2013)
Should I take this Nutritional Supplement with Cisplatin treatment?
Black seed : Black seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP2B6 and CYP3A4 interactions with Cisplatin treatment, and hence should not be used. Also, Black seed supplement does not show benefit on other biochemical pathways that could improve the Cisplatin treatment efficacy in this cancer. (Pius S Fasinu et al, Front Oncol., 2019; Vlastimil Masek et al, Anticancer Drugs., 2009; Ahmed A Albassam et al, Saudi Pharm J., 2018)
Example Foods to “Not Eat” and Eat with Fluorouracil treatment for Ampullary Carcinoma
Foods to Avoid with Fluorouracil treatment
Spearmint : Spearmint contains active ingredients such as Isothymonin, Vitamin C, D-limonene and others. Isothymonin interferes with the impact of Fluorouracil in Ampullary Carcinoma. Hence, do not eat Spearmint with Fluorouracil treatment for Ampullary Carcinoma.
Foods to Eat with Fluorouracil treatment
Lentils : Lentils contains active ingredients like Daidzein, Vitamin C and Ellagic Acid. Intake of Daidzein along with Fluorouracil treatment for Ampullary Carcinoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR, and this is a very positive effect. Lentils hence should be eaten with Fluorouracil treatment for Ampullary Carcinoma. (Sang Gwon Seo et al, Mol Nutr Food Res., 2013; Eun-Ji Kim et al, Oncotarget., 2018; Michael J Overman et al, PLoS One,. 2013)
Oat : Oat contains active ingredients like Vitamin E, Ferulic Acid and Quercetin. Intake of Vitamin E along with Fluorouracil treatment for Ampullary Carcinoma causes a decrease in specific biochemical pathways called MAPK and PI3K-AKT-MTOR, and this is a very positive effect. Oat hence should be eaten with Fluorouracil treatment for Ampullary Carcinoma. (G V Saman et al, Cell Prolif., 2006; Wenguang Sun et al, Br J Nutr., 2008; Eun-Ji Kim et al, Oncotarget., 2018; Michael J Overman et al, PLoS One,. 2013)
Should I take this Nutritional Supplement with Fluorouracil treatment?
Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP1A2 interactions with Fluorouracil treatment, and hence should not be used. Black Seed supplement does not show benefit on other biochemical pathways that could improve the Cisplatin treatment efficacy in Ampullary Carcinoma. (Ahmed A Albassam et al, Saudi Pharm J., 2018; T Komatsu et al, Drug Metab Dispos., 2000)
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
What are the Symptoms of Ampullary Carcinoma?
In the initial stages, most cancers including Ampullary Carcinoma may not cause any signs or symptoms. However, as the disease progresses, it may start showing symptoms.
Following are some of the signs and symptoms that may be caused by Ampullary Carcinoma.
- Stomach pain
- Back pain
- Nausea and vomiting
- Clay-colored, greasy stools
- Rectal Bleeding
- Weight loss
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Ampullary Carcinoma.
What are the Treatment Options for Ampullary Carcinoma?
The treatment for Ampullary Carcinoma may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for Ampullary Carcinoma include:
- Whipple procedure (pancreaticoduodenectomy) – to remove the affected part of the ampulla of Vater and head of the pancreas.
- Minimally invasive surgery for those who can’t undergo Whipple procedure
- Combination of chemotherapy and radiotherapy
- Medications to reduce pain
As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Ampullary Carcinoma.
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Ampullary Carcinoma.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.