No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Schwannoma (Acoustic Neuroma and Malignant Schwannoma) needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Olive and Tomato should be eaten when undergoing Trametinib treatment for Schwannoma. On the same lines, foods like Green Bean and Spinach should be avoided with treatment of Trametinib for Schwannoma.
Vitamin D3 has no reported interactions with Trametinib and can help improve the treatment efficacy.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Schwannoma.
What is Schwannoma?
Schwannoma is a tumor that develops from the Schwann cells in the peripheral nervous system. It grows in the sheaths of nerves – the tissue that covers nerves. Schwannomas are usually benign and harmless and are called Vestibular schwannoma or acoustic neuroma, however, rarely schwannomas may be malignant or cancerous. Schwannoma that develops in the nerve connecting the brain to the inner ear is called vestibular schwannoma or acoustic neuroma.
The incidence rate of this cancer is only 1 per 1 lakh people per year. Schwannoma is commonly diagnosed in people who are about 53 years of age, however, it can occur in people of any age. It is commonly found in Asians followed by Whites and Hispanic as compared to African Americans.
Schwannoma has prevalence of certain genetic changes. Some of the genes such as neurofibromatosis 2 (NF2), ARID1A, FANCD2, and APC are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in Schwannoma can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Schwannoma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Schwannoma genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Schwannoma (Acoustic Neuroma and Malignant Schwannoma) may have to be redesigned.
Why Eating Right Matters for Schwannoma?
In Schwannoma, activation or inhibition of some of the biochemical pathways including PI3K-AKT-MTOR Signaling, MAPK Signaling, WNT beta catenin Signaling, Cell Cycle and Cancer Epigenetics plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Schwannoma (acoustic neuroma and malignant schwannoma), eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Trametinib treatment for Schwannoma
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show examples of diet/nutrition to take and avoid for Schwannoma based on a specific treatment.
Foods to Avoid with Trametinib treatment
Green Bean : Green Bean contains active ingredients such as Kaempferol, Linoleic Acid, Astragalin and others. Kaempferol interferes with the impact of Trametinib in Schwannoma by activating a specific biochemical pathway called WNT beta catenin signaling. Hence, do not eat Green Bean with Trametinib treatment for Schwannoma. (M Hasegawa et al, Histol Histopathol., 2002; Heshu Lu et al, J Med Chem., 2005; Limin Zhang et al, PLoS One., 2016; Shanthi Ganesh et al, Mol Cancer Ther., 2018)
Spinach : Spinach contains active ingredients such as Kaempferol, Linoleic Acid, Folic Acid and others. Kaempferol interferes with the impact of Trametinib in Schwannoma by activating a specific biochemical pathway called WNT beta catenin signaling. Hence, do not eat Spinach with Trametinib treatment for Schwannoma. (M Hasegawa et al, Histol Histopathol., 2002; Heshu Lu et al, J Med Chem., 2005; Limin Zhang et al, PLoS One., 2016; Shanthi Ganesh et al, Mol Cancer Ther., 2018)
Foods to Eat with Trametinib treatment
Olive : Olive contains active ingredients like Betulinic Acid, Corosolic Acid and Linoleic Acid. Intake of Betulinic Acid along with Trametinib treatment for Schwannoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Olive hence should be eaten with Trametinib treatment for Schwannoma. (Weiping Liu et al, Am J Transl Res., 2019; Sameer Agnihotri et al, Neuro Oncol., 2014 – Nov; 16(Suppl 5): v127; Tina X Lee et al, Y Linda Wu et al, Transl Oncol., 2017)
Tomato : Tomato contains active ingredients like Lupeol, Linoleic Acid and Lutein. Intake of Lupeol along with Trametinib treatment for Schwannoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Tomato hence should be eaten with Trametinib treatment for Schwannoma. (Lingli Zhang et al, Eur J Pharmacol., 2015; Sameer Agnihotri et al, Neuro Oncol., 2014 – Nov; 16(Suppl 5): v127; Tina X Lee et al, Y Linda Wu et al, Transl Oncol., 2017)
Should I take this Nutritional Supplement with Trametinib treatment?
Vitamin D3 : Vitamin D3 has no known reported CYP (drug metabolizing enzyme) interactions with Trametinib treatment. Vitamin D3 supports the Trametinib treatment for Schwannoma because of activation of Adherens junction and inhibition of DNA Repair, Epithelial to Mesenchymal Transition, Growth Factor Signaling, PI3K-AKT-MTOR Signaling, Amino Acid Metabolism. (Reyhaneh Salehi-Tabar et al, Proc Natl Acad Sci U S A., 2012; H G Pálmer et al, J Cell Biol., 2001; Linara S Axanova et al, Prostate., 2010)
Impact of Different Natural products on Schwannoma Growth – In vitro Experimental studies
1. Sulforaphane may Inhibit Vestibular Schwannoma (Acoustic Neuroma) Growth
An experimental study done by the researchers from Soonchunhyang University College of Medicine in Korea, Kindai University Faculty of Medicine in Japan, Massachusetts Eye and Ear Infirmary in Boston, Harvard Medical School in MA, USA, Yonsei University College of Medicine in Seoul, Korea and Korea Research Institute of Bioscience and Biotechnology in Cheongju, Korea found that Sulforaphane, a key active compound found in cruciferous vegetables, such as broccoli, had significant antiproliferative activity in schwannoma cells and induced apoptosis and cell cycle arrest. (Bo Gyung Kim et al, Sci Rep,. 2016)
2. Honokiol may Inhibit Vestibular Schwannoma (Acoustic Neuroma) Growth
Another experimental study done by the researchers from the Soonchunhyang University College of Medicine, in Korea found that Honokiol, a low molecular weight natural product from Magnolia officinalis, could inhibit cell proliferation and promote apoptosis in schwannoma cells by targeting the ERK/MAPK pathway. (Jong Dae Lee et al, Laryngoscope., 2012)
3. Tanshinone II A may Inhibit Vestibular Schwannoma (Acoustic Neuroma) Growth
A laboratory study done by the Soonchunhyang University College of Medicine, Korea University College of Medicine and University of Science and Technology in Republic of Korea found that tanshinone II A, one of the key bioactive compounds present in the root of Salvia miltiorrhiza, inhibited Schwannoma cell proliferation and it inhibited Vestibular Schwannoma Cells by suppressing the activity of a gene called HIF‑1α. Based on the findings, the study concluded that tanshinone II A may be a potential chemotherapeutic agent for the treatment of Vestibular Schwannoma. (Ju Yeon Kim et al, Mol Med Rep,. 2015)
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
What are the Symptoms of Schwannoma?
In the initial stages, most cancers including Schwannoma may not cause any signs or symptoms. However, as the disease progresses, Schwannoma cases may start showing symptoms due to direct impact on the nerve or due to the tumor putting pressure on the nearby nerves and blood vessels.
Following are some of the signs and symptoms that may be caused by Schwannoma.
- A visible lump under the skin
- Muscle weakness
- Pricking and sharp pains
- Pins and needle sensation
- Loss of balance
- Neck or back pain at night
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Schwannoma.
What are the Treatment Options for Schwannoma?
The treatment for Schwannoma may be decided based on different factors including the type of cancer, patient’s general health and medical history, what nerves and other tissues it affects, symptoms, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for Schwannoma include:
As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Schwannoma (acoustic neuroma and malignant schwannoma).
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Schwannoma (acoustic neuroma and malignant schwannoma).
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.