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What should I Eat?

is the most common question asked by cancer patients.
Choose food and nutritional supplements which reduces adverse interactions with your cancer treatment and support them.

is the most common question asked by cancer patients. Choose food and nutritional supplements which reduces adverse interactions with your cancer treatment and support them.

Get your personalized nutrition plan for cancer at 

Get your personalized nutrition plan for cancer at

Diet for Lung Neuroendocrine Tumor – A Rare Cancer

Mar 4, 2021

Highlights

When it comes to managing a rare cancer such as Lung Neuroendocrine Tumor, taking the right foods and supplements as part of the diet matters. Heavy meals, fatty foods, amine rich foods and alcoholic beverages should be avoided by neuroendocrine tumor patients with carcinoid syndromes. While Bittermelon and Blackberry are recommended to be included as part of the diet when undergoing treatment with standard therapies such as Eribulin/Trabectedin for Lung Neuroendocrine Tumor, Lard and Tallow should be avoided from the diet. Hence, following a personalized nutrition/diet plan customized for the specific cancer type and treatment is essential to stay safe, reduce symptoms and obtain maximum nutritional benefits while undergoing treatment for any cancer including Lung Neuroendocrine Tumor.



What is Lung Neuroendocrine Tumor?

Lung Neuroendocrine Tumor is a rare neuroendocrine tumor that develops in the lungs. It constitutes about 20% of all neuroendocrine tumors. This cancer is commonly diagnosed in people who are about 45 to 60 years of age, however, it can occur in people of any age. It is commonly found in white people as compared to other ethnic groups. The 5-year survival rate of Lung Neuroendocrine Tumors that have spread to other parts of the body is 58%. (https://www.cancer.net/)

Symptoms, Treatment and Diet for Lung Neuroendocrine Tumor - A Rare Cancer

Lung Neuroendocrine Tumor has prevalence of certain genetic changes. Some of the genes such as TP53, MLLT3, IL21R, UIMC1 and ARID1A are known to have genetic abnormalities in this cancer resulting in a change of function. 

The genetic abnormalities found in Lung Neuroendocrine Tumor can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment.  In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Lung Neuroendocrine Tumor. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Lung Neuroendocrine Tumor genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the cancer nutrition plan may have to be redesigned. 

Top 10 Foods and Supplements to Avoid for Cancer

Go beyond same nutrition guidelines for everyone and make personalized decisions with confidence.

What are the Symptoms of Lung Neuroendocrine Tumor?

In the initial stages, most cancers including Lung Neuroendocrine Tumor may not cause any signs or symptoms. However, as the disease progresses, it may start showing symptoms. 

Following are some of the signs and symptoms that may be caused by Lung Neuroendocrine Tumor.

  • Persistent cough
  • Coughing up blood
  • Frequent lung infections including bronchitis and pneumonia
  • Wheezing
  • Shortness of breath
  • Chest pain
  • Hoarseness
  • Fatigue
  • Carcinoid syndrome.

Also, about 10% of Neuroendocrine Cancers of the Lung may show symptoms of Carcinoid Syndrome including flushing of the skin, faster heart rate and breathlessness.

Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Lung Neuroendocrine Tumor.

What are the Treatment Options for Lung Neuroendocrine Tumor?

The treatment for Lung Neuroendocrine Tumor may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for Lung Neuroendocrine Tumor include:

  • Surgery
  • Statin analogs
  • Chemotherapy
  • Targeted therapy
  • Radiation therapy
  • Peptide receptor radionuclide therapy (PRRT)

Association of Different Foods and Supplements with Lung Neuroendocrine Tumor

In Lung Neuroendocrine Tumor, biochemical pathways including Growth Factor Signaling, MYC Signaling, PI3K-AKT-MTOR Signaling, and NFKB Signaling get activated to drive the disease. All food and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain food and nutritional supplements may support a specific treatment of Lung Neuroendocrine Tumor, eating few other food and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.

Examples of Foods/Supplements To Take and Avoid when undergoing Treatment with Standard Therapies like Eribulin and Trabectedin

Foods to Take 

Bittermelon : Bittermelon contains many active ingredients including ferulic acid, acteoside, beta-sitosterol and others. Intake of ferulic acid along with Eribulin/Trabectedin treatment for Lung Neuroendocrine Tumor decreases Growth Factor Signaling, MYC Signaling, PI3K-AKT-MTOR Signaling, NFKB Signaling and proliferation which is beneficial. Hence, Bittermelon is recommended to be included as part of the diet when undergoing treatment with Eribulin/Trabectedin for this cancer. (Guang-Wei Yang et al, Int J Mol Sci., 2015; Nadia Lampiasi et al, Immunobiology., Apr-May 2018)

Blackberry : Blackberry contains active ingredients including hyperoside, cianidanol, geraniin and others. Intake of hyperoside along with  Eribulin/Trabectedin treatment for Lung Neuroendocrine Tumor decreases MYC Signaling, PI3K-AKT-MTOR Signaling, NFKB Signaling and proliferation which is beneficial. Hence, Blackberry is recommended to be included as part of diet when undergoing treatment with  Eribulin/Trabectedin for this cancer. (Yu Yang et al, Int J Clin Exp Pathol., 2017; Yuan-huaLiu et al, Sci Dir., 2016)

Foods to Avoid

Lard : Lard contains different active ingredients including myristic acid, palmitic acid and others.  Myristic acid increases MYC signaling and proliferation. Hence, Lard should be avoided from the diet while undergoing treatment with standard therapies such as Eribulin/Trabectedin for Lung Neuroendocrine Tumor. (Li Zeng et al, PLoS One., 2008; Sungjin Kim et al, J Biol Chem., 2017)

Tallow : Tallow contains different active ingredients including myristic acid, palmitic acid, lauric acid and others.  As highlighted before, Myristic acid increases MYC signaling and proliferation. Hence, Tallow should be avoided from the diet while undergoing treatment with standard therapies such as Eribulin/Trabectedin for this cancer. (Li Zeng et al, PLoS One., 2008; Sungjin Kim et al, J Biol Chem., 2017)

Supplements to Take or Avoid

Thyme : Thyme contains active ingredients like apigenin which has reported CYP3A4 interactions with Eribulin/Trabectedin treatment. This can lead to toxicity or impact the treatment efficacy due to the impact on the active drug concentration levels. (Darija Šarić Mustapić et al, Molecules., 2018; Z-Y Zhang et al, Cancer Chemother Pharmacol., 2008)

Vitamin K : A case report has shown that a protein produced during Vitamin K deficiency induced large cell neuroendocrine carcinoma (LCNEC) of lung with multiple liver metastases. Hence, Vitamin K supplementation may be beneficial. (Hirokazu Kurohama et al, Pathol Int., 2017)

Additionally, Neuroendocrine Tumor patients with carcinoid symptoms should avoid:

  • Heavy meals, and eat regular, smaller meals
  • High fat foods such as red meat and add lean meat such as fish
  • Foods rich in amines such as tyramine, dopamine and histamine as it can lead to flushing
  • Alcoholic beverages
  • Aged cheeses
  • Smoked, salted, or pickled fish and meats
  • Yeast extracts
  • Fermented foods such as tofu, soy sauce, miso, sauerkraut, fish sauce

Science of Right Personalized Nutrition for Cancer

Conclusion

While Bittermelon and Blackberry are recommended to be included as part of diet when undergoing treatment with Eribulin/Trabectedin for Lung Neuroendocrine Tumor,  Lard and Tallow should be avoided. Additionally, allergies need to be also considered when mapping these lists of foods and nutritional supplements to come up with a diet plan for any cancer including Lung Neuroendocrine Tumor. Neuroendocrine tumor patients with carcinoid syndromes should avoid heavy meals, fatty foods, amine rich foods and alcoholic beverages.

“What should I eat?” is the most frequently asked question to cancer dieticians and physicians. The right answer depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan keeps you safe from adverse nutrition interactions.

Get started NOW with answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

Top 10 Foods and Supplements to Avoid for Cancer

Go beyond same nutrition guidelines for everyone and make personalized decisions with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.